1. [Neuropsychiatric complication after surgical procedures--literature review].
- Author
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Czech B, Kucewicz E, and Frank M
- Subjects
- Antipsychotic Agents therapeutic use, Delirium drug therapy, Delirium etiology, Humans, Ondansetron therapeutic use, Serotonin Antagonists therapeutic use, Cardiac Surgical Procedures adverse effects, Cardiac Surgical Procedures psychology, Mental Disorders etiology, Nervous System Diseases etiology
- Abstract
2-3% of patients after cardiac procedures with the use of cardiopulmonary by-pass develop neurological complications with focal symptoms. Also to there may be mental, emotional and intellectual disturbances. This kind of complications occurs in 33-83% of patients. The post-cardiopulmonary by-pass delirium is a syndrome with diverse symptoms. Confusion, hallucinations, paranoid illusions, psycho-motoric excitation, fear may also occur. A high level of serotonin and overstimulation of 5-HT2 receptors in the central nervous system are the reason of delirium. The relief of symptoms may be achieved by intravenous administration of Ondansetron, an antagonist of 5-HT2 receptors.
- Published
- 2003