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FLake has been one of the most extensively used lake models in many studies for lake thermal structure simulations. However, due to the scarcity of lake temperature observations, its applicability and performance on lakes over the Tibetan Plateau are still poorly investigated, especially in small- to medium-sized lakes. In this study, based on water profile observations in Dagze Co, a medium-sized lake on the central Tibetan Plateau, the sensitivity of lake thermal features to three key parameters in FLake was investigated. The performance of FLake in reproducing the lake thermal features was evaluated and improved by optimizing these key parameters. The results showed that the FLake model with default parameter settings can generally reproduce the thermal features of Dagze Co, but there are still significant deviations compared to observation. The sensitive experiments demonstrated that the thermal structure of the lake obviously responds to the change in the water extinction coefficient (Kd), friction velocity (u*), and ice albedo ( α i c e ). Based on previous studies and sensitive experiments, the three key parameters were set to the optimized value, which substantially improved the performance of FLake. The values of bias and RMSE of simulated lake surface water temperature decreased from 3.08 °C and 3.62 °C to 2.0 °C and 2.48 °C after parameter optimization. The integration of a simple salinity scheme further improved the ability of FLake to reproduce the observed thermal features of Dagze Co. These results will improve our understanding of thermal processes in lakes on the Tibetan Plateau, as well as the applicability of lake models. [ABSTRACT FROM AUTHOR]