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A study of the content of cyclic nucleotides in patients with chronic gastritis indicates that the level of cAMP and cGMP undergoes various changes. The cGMP/cAMP ratio was in gastritis of the A type higher than in the healthy and in the B gastritis type lower. It is concluded that chronic gastritis is accompanied not only by changes of absolute values of the level of cyclic nucleotides but also by changes of the cGMP/cAMP ratio.

The content of basal gastrin and ultrastructure of gastrinproducing cells was studied in 81 patients showing chronic gastritis with secretory insufficiency. The highest level of gastrin was revealed in the blood of patients with diffuse atrophic gastritis, moderately increased--focal atrophic gastritis. The blood gastrin was reduced in patients with antral gastritis. A study of the ultrastructure of gastrinproducing cells revealed their high functional activity in diffuse atrophic gastritis and a moderate in focal atrophic gastritis. Changes of the gastrin level and ultrastructure of gastrinproducing cells should be considered in the choice of treatment methods.

The content of prostaglandins E(PGE) and prostaglandins F2 alpha (PGF2 alpha) was studied in 32 patients with different morphological forms of chronic gastritis at the stage of exacerbation before and after treatment. The PGE content was increased and the PGF2 alpha level was reduced. At the beginning of remission the PGE level was reduced. At the beginning of remission the PGE level decreased as compared with findings before the beginning of treatment while the content of PGF2 alpha did not show essential changes.