1. Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems.
- Author
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Leitner, G. C., Gruber, R., Neumüller, J., Wagner, A., Kloimstein, P., Höcker, P., Körmöczi, G. F., and Buchta, C.
- Subjects
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BLOOD plasma , *BLOOD platelets , *GROWTH factors , *BLOOD cells , *CYTOKINES - Abstract
Background Different systems for preparation of platelet-rich plasma are commercially available, but data for comparison of these systems have not been published so far. Materials and Methods We investigated the performance of Vivostat PRF Preparation Kit®, PCCS Platelet Concentrate Collection System®, Harvest® SmartPReP 2 APC 60 Process, and Fibrinet® Autologous Fibrin & Platelet System. The preparations provided by these systems are platelet concentrates with high numbers of platelets in a small volume of plasma and PDGF-AB is released continuously during the 5 days after preparation. Results Vivostat PRF Preparation Kit, PCCS Platelet Concentrate Collection System, Harvest SmartPReP 2 APC 60 Process are comparable in platelet yield and total amount of released PDGF-AB after 120 h while with Fibrinet the lowest platelet yield and PDGF-AB content of supernatant was achieved. The ability of growth factor release was equal in all four systems. Conclusion In conclusion, all four systems for preparation of platelet-rich plasma investigated result in considerable growth factor release. In what extent the total content of PDGF-AB as a consequence of platelet yield has an impact on wound healing has to be further investigated [ABSTRACT FROM AUTHOR]
- Published
- 2006
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