1. Autologous bone marrow-derived progenitor cell transplantation for myocardial regeneration after acute infarction.
- Author
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Obradovic, Slobodan, Rusovic, Sinisa, Balint, Bela, Ristic-Andelkov, Andelka, Romanovic, Radoslav, Baskot, Branislav, Vojvodic, Danilo, and Gligic, Branko
- Subjects
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MYOCARDIAL infarction , *STEM cell transplantation , *CARDIAC regeneration , *ANGIOPLASTY , *THERAPEUTICS - Abstract
Background. Experimental and first clinical studies suggest that the transplanlation of bone marrow derived, or circulating blood progenitor cells, may beneficially affect postinfarction remodelling processes after acute myocardial Infarction. Aim. This pilot trial reports investigation of safety and feasibility of autologous bone marrow-derived progenitor cell therapy for faster regeneration of the myocardium after infarction. Methods and results. Four male patients (age range 47-68 years) with the first extensive anterior, ST elevation, acute myocardial infarction (AMI), were treated by primary angioptasty. Bone marrow mononuclear cells were administered by intracoronary infusion 3-5 days after the infarction. Bone marrow was harvested by multiple aspirations from posterior cristae iliacae under general anesthesia, and under aseptic conditions. After that, cells were filtered through stainless steel mesh, centri-fuged and resuspended in serum-free culture medium, and 3 hours later infused through the catheter into the infarct-related artery in 8 equal boluses of 20 ml. Myocardial viability in the infarcted area was confirmed by dobutamin stress echocardiography testing and single-photon emission computed tomography (SPECT) 10-14 days after infarction. One patient had early stent thrombosis immediately before cell transplantation, and was treated successfully with second angioplasty. Single average ECG revealed one positive finding at discharge, and 24-hour Hotter ECG showed only isolated ventricular ectopic heats during the follow-up period. Early findings in two patients showed significant improvement of left ventricular systolic function 3 months after the infarction. There were no major cardiac events after the transplantation during further follow-up period (30-120 days after infarction). Control SPECT for the detection of ischemia showed significant improvement in myocardial perfusion in two patients 4 months after the infarction.... [ABSTRACT FROM AUTHOR]
- Published
- 2004
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