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Your search keyword '"Stett, A"' showing total 4 results
Start Over Author "Stett, A" Journal vision research
4 results on '"Stett, A"'

1. Can subretinal microphotodiodes successfully replace degenerated photoreceptors?

Author

Zrenner, E, Stett, A, Weiss, S, Aramant, RB, Guenther, E, Kohler, K, Miliczek, K-D, Seiler, MJ, and Haemmerle, H

Subjects
Eye Disease and Disorders of Vision, Rehabilitation, Neurosciences, Bioengineering, Assistive Technology, Eye, Animals, Biocompatible Materials, Blindness, Electronics, Medical, Electroretinography, In Vitro Techniques, Light, Miniaturization, Prostheses and Implants, Rats, Retina, Retinal Degeneration, Semiconductors, Time Factors, visual prosthesis, subretinal implant, subretinal microphotodiodes, photoreceptor replacement, retinal degeneration, Medical and Health Sciences, Psychology and Cognitive Sciences, Experimental Psychology
Abstract

The idea of implanting microphotodiode arrays as visual prostheses has aroused controversy on its feasibility from the moment it appeared in print. We now present results which basically support the concept of replacing damaged photoreceptors with subretinally implanted stimulation devices. Network activity in degenerated rat retinae could be modulated through local electrical stimulation in vitro. We also investigated the long term stability and biocompatibility of the subretinal implants and their impact on retinal physiology in rats. Ganzfeld electroretinograms and histology showed no significant side effect of subretinal implants on retinal function or the architecture of the inner retina.

Published
1999

2. Can subretinal microphotodiodes successfully replace degenerated photoreceptors?

Author

Elke Guenther, Alfred Stett, Magdalene J. Seiler, Stefan Weiss, Eberhart Zrenner, Konrad Kohler, K.-D. Miliczek, Hugo Haemmerle, and Robert B. Aramant

Subjects
Retinal degeneration, Subretinal microphotodiodes, Time Factors, genetic structures, Light, Stimulation, Biocompatible Materials, Eye, Blindness, Medical and Health Sciences, chemistry.chemical_compound, Photoreceptor replacement, Subretinal implant, Assistive Technology, medicine.diagnostic_test, Rehabilitation, Retinal Degeneration, Experimental Psychology, Prostheses and Implants, Sensory Systems, medicine.anatomical_structure, Visual prosthesis, medicine.medical_specialty, Biocompatibility, Bioengineering, In Vitro Techniques, Retina, Optics, Medical, Ophthalmology, medicine, Electroretinography, Animals, Eye Disease and Disorders of Vision, Miniaturization, business.industry, Psychology and Cognitive Sciences, Neurosciences, Retinal, medicine.disease, eye diseases, Electronics, Medical, Rats, chemistry, Semiconductors, Retinal function, sense organs, Electronics, business
Abstract

The idea of implanting microphotodiode arrays as visual prostheses has aroused controversy on its feasibility from the moment it appeared in print. We now present results which basically support the concept of replacing damaged photoreceptors with subretinally implanted stimulation devices. Network activity in degenerated rat retinae could be modulated through local electrical stimulation in vitro. We also investigated the long term stability and biocompatibility of the subretinal implants and their impact on retinal physiology in rats. Ganzfeld electroretinograms and histology showed no significant side effect of subretinal implants on retinal function or the architecture of the inner retina.

Published
1999
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4. Electrical multisite stimulation of the isolated chicken retina

Author

Eberhart Zrenner, Hugo Haemmerle, Wolfgang Barth, Alfred Stett, and Stefan Weiss

Subjects
Retinal degeneration, genetic structures, Subretinal stimulation, Stimulation, Electric Stimulation Therapy, Neurotransmission, Prosthesis Design, Synaptic Transmission, Retina, chemistry.chemical_compound, Functional electrical stimulation, medicine, Animals, Humans, Microelectrode array, Depth Perception, Chemistry, Retinal Degeneration, Retinal, Multielectrode array, medicine.disease, Sensory Systems, Electric Stimulation, Form Perception, Ophthalmology, Microelectrode, medicine.anatomical_structure, Visual prosthesis, Retina preparation, Ganglia, Neuroscience, Chickens, Microelectrodes, Biomedical engineering
Abstract

Visual prostheses such as subretinal implants are intended for electrical multisite excitation of the retinal network. To investigate relevant issues like spatial resolution and operational range, we have developed an in vitro method using microelectrode arrays to stimulate isolated retinae. Ganglion cell activity in the chicken retina evoked by distally applied spatial voltage patterns consisted of fast bursts, transient inhibition and delayed discharges, and depended on the amount, location and spatial pattern of the injected charge. The response was altered or disappeared when synaptic transmission was blocked. Our results indicate that shape perception and object location can be partially achieved with subretinal electrical multisite stimulation.

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