1. The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States.
- Author
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Smith CP, Hartman RM, Kugler AM, Little V, Baker OR, Fairlie TA, Fernandez RE, Hagen MB, Honie E, Laeyendecker O, Midgley CM, Parker D, Sandoval M, Takahashi S, Hammitt LL, and Sutcliffe CG
- Subjects
- Humans, Adult, Child, Female, Male, Adolescent, Southwestern United States epidemiology, Young Adult, Antibody Formation, Indigenous Peoples, Middle Aged, Child, Preschool, Vaccination, COVID-19 immunology, COVID-19 epidemiology, Antibodies, Viral blood, Antibodies, Viral immunology, SARS-CoV-2 immunology, Spike Glycoprotein, Coronavirus immunology
- Abstract
SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentrations and decay rates estimated that one year after infection, participants would serorevert for anti-nucleocapsid antibodies and remain seropositive for anti-spike antibodies. The peak anti-spike concentrations were higher for individuals vaccinated prior to infection, but the decay rates were similar across immunologic status groups. Children had significantly lower peak anti-spike concentrations than adults. This study affirms the importance of continued vaccination to maintain high levels of immunity in the face of waning immunity.
- Published
- 2024
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