1. Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
- Author
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Katie R. Hagen, Debbie Douglas, Danny Ragland, Kurt Cooper, John G. Bernbaum, Krisztina Janosko, Jeffrey Solomon, James Pettitt, Reed F. Johnson, Peter B. Jahrling, Marisa St. Claire, Nicole Josleyn, Timothy K. Cooper, David Thomasson, Jens H. Kuhn, Andrew E. Arai, Lauren Keith, Srikanth Yellayi, Mark Martinez, and Robin Gross
- Subjects
Male ,Myocarditis ,VARV ,Cowpox ,viruses ,CPXV ,Hemorrhage ,Disease ,Microbiology ,complex mixtures ,Article ,Virology ,medicine ,Hemorrhagic smallpox ,Coagulopathy ,cardiac MRI ,Smallpox ,Animals ,Cowpox virus ,biodefense ,business.industry ,virus diseases ,medicine.disease ,cowpox ,QR1-502 ,smallpox ,Disease Models, Animal ,Macaca fascicularis ,Infectious Diseases ,variola ,Acute Disease ,Female ,Variola virus ,business - Abstract
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.
- Published
- 2021