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Your search keyword '"D. Botta-Fridlund"' showing total 3 results
Start Over Author "D. Botta-Fridlund" Journal virology
3 results on '"D. Botta-Fridlund"'

1. Hepatitis B virus reactivation in HBsAg-negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase

Author

Anne Motte, Catherine Tamalet, René Gerolami, D. Botta-Fridlund, Aude Charbonnier, Patrick Borentain, Julie Bertrand, Diane Coso, Jacques Serratrice, Isabelle Portal, Thérèse Aurran-Schleinitz, Anne-Marie Stoppa, Fabrice Barlesi, Mélanie Serrero, Christian Chabannon, and Philippe Colson

Subjects
Adult, Male, Hepatitis B virus, HBsAg, Hepatitis B virus DNA polymerase, Antineoplastic Agents, Biology, medicine.disease_cause, Hepatitis B virus PRE beta, Serology, Neoplasms, Virology, HBV therapy, medicine, Chemotherapy, Humans, HBV-DNA detection, Aged, Hepatitis B virus reactivation, Hepatitis B Surface Antigens, Nucleoside analogue, virus diseases, RNA-Directed DNA Polymerase, Middle Aged, Resistance mutation, digestive system diseases, Reverse transcriptase, Female, Mutant Proteins, Virus Activation, medicine.drug
Abstract

Background/aims Virological factors associated with hepatitis B virus reactivation (HBV-R), following chemotherapy for cancer in hepatitis B surface antigen (HBsAg)-negative patients, are not well known. Materials and methods HBV strains from 16 patients presenting HBV-R following chemotherapy were studied and compared to those obtained from 51 HBV chronically-infected patients. Results HBsAg variability was significantly increased within the major hydrophilic region, the a determinant and the C-terminal region. Amino acid substitutions were more frequently found in HBV-R patients as compared to controls at 17 and 11 positions within HBsAg and HBV-RT, respectively. This resulted in atypical serological testing in 56% of patients and detection of resistance mutation to nucleoside analogs in 12.5%. Conclusion HBsAg and HBV-RT mutations are frequently encountered in patients with HBV-R, resulting in atypical serological testing and emergence of HBV strains resistant to nucleos(t)ides analogs.

Published
2015

2. Hepatitis B virus reactivation in HBsAg-negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase.

Author

Colson P, Borentain P, Coso D, Motte A, Aurran-Schleinitz T, Charbonnier A, Stoppa AM, Chabannon C, Serrero M, Bertrand J, Barlesi F, Serratrice J, Portal I, Botta-Fridlund D, Tamalet C, and Gerolami R

Subjects
Adult, Aged, Antineoplastic Agents therapeutic use, Female, Hepatitis B virus genetics, Humans, Male, Middle Aged, Mutant Proteins genetics, Neoplasms drug therapy, Hepatitis B Surface Antigens blood, Hepatitis B Surface Antigens genetics, Hepatitis B virus physiology, RNA-Directed DNA Polymerase genetics, Virus Activation
Abstract

Background/aims: Virological factors associated with hepatitis B virus reactivation (HBV-R), following chemotherapy for cancer in hepatitis B surface antigen (HBsAg)-negative patients, are not well known., Materials and Methods: HBV strains from 16 patients presenting HBV-R following chemotherapy were studied and compared to those obtained from 51 HBV chronically-infected patients., Results: HBsAg variability was significantly increased within the major hydrophilic region, the a determinant and the C-terminal region. Amino acid substitutions were more frequently found in HBV-R patients as compared to controls at 17 and 11 positions within HBsAg and HBV-RT, respectively. This resulted in atypical serological testing in 56% of patients and detection of resistance mutation to nucleoside analogs in 12.5%., Conclusion: HBsAg and HBV-RT mutations are frequently encountered in patients with HBV-R, resulting in atypical serological testing and emergence of HBV strains resistant to nucleos(t)ides analogs., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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3. Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers.

Author

Colson P, Borentain P, Motte A, Henry M, Moal V, Botta-Fridlund D, Tamalet C, and Gérolami R

Subjects
Adult, Aged, Aged, 80 and over, Amino Acid Substitution, Female, France epidemiology, Genotype, HIV Reverse Transcriptase genetics, Hepatitis B virus genetics, Hepatitis B virus immunology, Hospitals, Public, Humans, Male, Middle Aged, Prevalence, Carrier State epidemiology, Carrier State immunology, Carrier State physiopathology, Carrier State virology, Hepatitis B Antibodies blood, Hepatitis B Surface Antigens blood, Hepatitis B virus isolation & purification, Hepatitis B, Chronic epidemiology, Hepatitis B, Chronic immunology, Hepatitis B, Chronic physiopathology, Hepatitis B, Chronic virology
Abstract

The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with HBsAg-amino acid (aa) substitutions. However, the aa pattern of HBV-reverse transcriptase (RT) and the clinical settings associated with this serological profile remain largely unknown. We studied thirteen HBsAg-positive/HBsAb-positive patients. Newly diagnosed HBsAg-positive/HBsAb-negative patients (n=51) served as controls. HBsAg/RT sequences were obtained using in-house protocols. HBsAg-positive/HBsAb-positive patients were predominantly immunosuppressed (69%). Five presented advanced liver fibrosis. HBV DNA >5.0 log(10) copies/ml was significantly more frequent than in controls. A significantly higher aa variability was observed versus controls within HBsAg major hydrophilic region (MHR), especially the a-determinant, and within RT for regions overlapping the MHR, the a-determinant, and HBsAg C terminal region where drug resistance mutations occur. Further studies are needed to determine whether this higher HBsAg/HBV-RT variability might favor dissemination of anti-HBsAb escape HBV mutants and concomitantly alter nucleos(t)ide analogs efficacy.

Published
2007
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