1. Identification and pathogenicity of a natural reassortant between a very virulent serotype 1 infectious bursal disease virus (IBDV) and a serotype 2 IBDV.
- Author
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Jackwood DJ, Sommer-Wagner SE, Crossley BM, Stoute ST, Woolcock PR, and Charlton BR
- Subjects
- Animals, Base Sequence, Chickens virology, Poultry Diseases epidemiology, Poultry Diseases virology, RNA, Viral analysis, RNA, Viral genetics, Recombination, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA, Serotyping, Turkeys virology, Birnaviridae Infections mortality, Birnaviridae Infections pathology, Birnaviridae Infections veterinary, Birnaviridae Infections virology, Infectious bursal disease virus classification, Infectious bursal disease virus genetics, Infectious bursal disease virus immunology, Infectious bursal disease virus pathogenicity, Reassortant Viruses genetics, Reassortant Viruses isolation & purification, Reassortant Viruses pathogenicity
- Abstract
Infectious bursal disease virus (IBDV) causes an economically important, immunosuppressive disease in chickens. There are two serotypes of the virus that contain a bi-segmented double-stranded RNA genome. In December 2008, the first very virulent (vv)IBDV was identified in California, USA and in 2009 we isolated reassortant viruses in two different locations. Genome segment A of these reassortants was typical of vvIBDV serotype 1 but genome segment B was most similar to IBDV serotype 2. The CA-K785 reassortant caused 20% mortality in chickens but no morbidity or mortality in commercial turkey poults despite being infectious. There have been previous reports of natural reassortants between vvIBDV and other serotype 1 strains, but a natural reassortant between IBDV serotypes 1 and 2 has not been described. The apparent reassorting of California vvIBDV with an endemic serotype 2 virus indicates a common host and suggests vvIBDV may have entered California earlier than originally thought., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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