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Your search keyword '"Yongran Wu"' showing total 3 results
Start Over Author "Yongran Wu" Journal virologica sinica
3 results on '"Yongran Wu"'

1. Patients with Prolonged Positivity of SARS-CoV-2 RNA Benefit from Convalescent Plasma Therapy: A Retrospective Study

Author

Shangwen Pan, Lianguo Ruan, You Shang, Yongran Wu, Lu Chen, Lehao Ren, Ke Hong, Jiqian Xu, Chaolin Huang, Jiancheng Zhang, and Xiaobo Yang

Subjects
Male, 0301 basic medicine, China, medicine.medical_specialty, Convalescent plasma, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Immunology, Convalescent plasma therapy, Antibodies, Viral, Virus, 03 medical and health sciences, Medical microbiology, Virology, Internal medicine, Humans, Medicine, COVID-19 Serotherapy, Aged, Retrospective Studies, SARS-CoV-2, business.industry, Immunization, Passive, COVID-19, RNA, Retrospective cohort study, Length of Stay, Middle Aged, Viral Load, 030104 developmental biology, RNA, Viral, Molecular Medicine, Female, business, Viral load, Research Article, Prolonged positivity
Abstract

Convalescent plasma therapy has been implemented in a few cases of severe coronavirus disease 2019. No report about convalescent plasma therapy in treating patients with prolonged positivity of SARS-CoV-2 RNA has been published. In this study, we conducted a retrospective observational study in 27 patients with prolonged positivity of SARS-CoV-2 RNA, the clinical benefit of convalescent plasma therapy were analyzed. qRT-PCR test of SARS-CoV-2 RNA turned negative (≤ 7 days) in a part of patients (early negative group, n = 15) after therapy, others (late negative group, n = 12) turned negative in more than 7 days. Pulmonary imaging improvement was confirmed in 7 patients in early negative group and 8 in late negative group after CP therapy. Viral load decreased in early negative group compared with late negative group at day 3, 5, 7 after implementing convalescent plasma therapy. Patients in early negative group had a shorter median length of hospital stay. In conclusion, convalescent plasma therapy might help eliminate virus and shorten length of hospital stay in patients with prolonged positivity of SARS-CoV-2 RNA.

Published
2020
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2. Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak

Author

You Shang, Peng Zhou, Yongran Wu, Hong Liu, Yaxin Wang, Yin Yuan, Shangwen Pan, Shiying Yuan, Shunan Ruan, Shuzhen Wang, Ruiting Li, Jiancheng Zhang, Huaqing Shu, and Yaqi Ouyang

Subjects
Adult, Male, 0301 basic medicine, China, medicine.medical_specialty, 030106 microbiology, Immunology, Enzyme-Linked Immunosorbent Assay, Antibodies, Viral, medicine.disease_cause, COVID-19 Serological Testing, Serology, Young Adult, 03 medical and health sciences, Medical microbiology, Virology, medicine, Humans, Seroconversion, Pandemics, Antibody, Aged, Retrospective Studies, Coronavirus, Aged, 80 and over, biology, SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, Correction, Outbreak, Retrospective cohort study, Middle Aged, Nucleocapsid Proteins, Coronavirus disease 2019 (COVID-19), 030104 developmental biology, Immunoglobulin M, Immunoglobulin G, biology.protein, Molecular Medicine, Female, business, Contact tracing, Research Article
Abstract

The coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has spread around the world with high mortality. To diagnose promptly and accurately is the vital step to effectively control its pandemic. Dynamic characteristics of SARS-CoV-2-specific antibodies which are important for diagnosis of infection have not been fully demonstrated. In this retrospective, single-center, observational study, we enrolled the initial 131 confirmed cases of COVID-19 at Jin-Yin-Tan Hospital who had at least one-time antibody tested during their hospitalization. The dynamic changes of IgM and IgG antibodies to SARS-CoV-2 nucleocapsid protein in 226 serum samples were detected by ELISA. The sensitivities of IgM and IgG ELISA detection were analyzed. Result showed that the sensitivity of the IgG ELISA detection (92.5%) was significantly higher than that of the IgM (70.8%) (P

Published
2020
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3. Correction to: Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak

Author

Shunan Ruan, Shangwen Pan, You Shang, Jiancheng Zhang, Shiying Yuan, Ruiting Li, Hong Liu, Yaxin Wang, Huaqing Shu, Yaqi Ouyang, Shuzhen Wang, Yin Yuan, Peng Zhou, and Yongran Wu

Subjects
0301 basic medicine, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), biology, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Immunology, Outbreak, Virology, 03 medical and health sciences, 030104 developmental biology, biology.protein, Medicine, Molecular Medicine, Antibody, business
Abstract

Due to type-setting error, the affiliation of author Huaqing Shu and Shuzhen Wang was mislabeled.

Published
2020
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