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9. Epizootic Myocarditis Associated With Encephalomyocarditis Virus in a Group of Rhesus Macaques (Macaca mulatta).

Author

Masek-Hammerman, K., Miller, A. D., Lin, K. C., MacKey, J., Weissenböck, H., Gierbolini, L., Burgos, A., Perez, H., and Mansfield, K. G.

Subjects
MYOCARDITIS, ENCEPHALOMYOCARDITIS virus, RHESUS monkeys, EUTHANASIA of animals, DYSPNEA, EDEMA, POLYMERASE chain reaction, DISEASES
Abstract

Six cases of fatal myocarditis associated with encephalomyocarditis virus occurred over a 14-month period in a group of outdoor-housed juvenile rhesus macaques. All animals were younger than 3 years of age and died or were euthanized following acute onset of dyspnea or pulmonary effusion (3 of 6) or were found dead without premonitory signs (3 of 6). Gross findings included pulmonary congestion (6 of 6), variable degrees of pleural effusion (4 of 6), multifocal pale tan foci throughout the myocardium (3 of 6), hepatomegaly and hepatic congestion (3 of 6), and pericardial effusion (1 of 6). Histologically, affected myocardium was infiltrated multifocally by lymphoplasmacytic and histiocytic inflammation admixed with necrotic and degenerate myofibers and infrequent mineralization (6 of 6). Pulmonary edema was present in all animals. Encephalomyocarditis virus was confirmed in 6 of 6 hearts by immunohistochemistry, and virus was isolated from one case by polymerase chain reaction. Sequencing of virus isolated from 1 affected animal indicated infection with a novel encephalomyocarditis virus. Encephalomyocarditis virus should be considered as a differential etiology in outbreaks of myocarditis and pulmonary edema in juvenile primates. [ABSTRACT FROM PUBLISHER]

Published
2012
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10. A Sparsely Granulated, Nonsecreting Adenoma of the Pars Intermedia Associated with Galactorrhea in a Male Rhesus Monkey (Macaca mulatta)

Author

Chalifoux, L., MacKey, J., and King, N.

Abstract

A pituitary mass was found at necropsy of a male Macaca mulatta. Hematoxylin and eosin-stained sections were consistent with a chromophobe adenoma. Ultrastructural examination revealed the tumor to be comprised predominantly of sparsely granulated cells. The tumor cells were negative for prolactin, somatotropin, adrenocorticotropin, luteinizing hormone, and thyrotropin by the peroxidase anti-peroxidase method. Other major lesions were gynecomastia and galactorrhea, testicular atrophy, ankylosing spondylitis, and amyloid deposition in the liver, spleen, adrenal, and intestinal tract.

Published
1983
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