1. Canine distemper virus active infection in order Pilosa, family Myrmecophagidae, species Tamandua tetradactyla
- Author
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Kelly Cristiane Ito Yamauchi, Selwyn Arlington Headley, Amauri Alcindo Alfieri, Fabiana M. Boabaid, Luciana Sonne, Alice Fernandes Alfieri, Gabriela Molinari Darold, Michele Lunardi, and Alexandre Mendes Amude
- Subjects
0301 basic medicine ,Tamandua ,040301 veterinary sciences ,viruses ,Hemagglutinins, Viral ,Genome, Viral ,Microbiology ,Virus ,0403 veterinary science ,03 medical and health sciences ,Dogs ,Phylogenetics ,medicine ,Animals ,Distemper ,Nucleocapsid ,Distemper Virus, Canine ,Pathogen ,Phylogeny ,Canidae ,General Veterinary ,biology ,Phylogenetic tree ,Canine distemper ,Viral nucleocapsid ,Tamandua tetradactyla ,04 agricultural and veterinary sciences ,General Medicine ,Xenarthra ,biology.organism_classification ,medicine.disease ,Immunohistochemistry ,Virology ,Europe ,030104 developmental biology ,Brazil - Abstract
Canine distemper virus (CDV) is a highly contagious disease pathogen which causes disease in the domestic dog and species classified in the Canidae, Procyonidae, Mustelidae, Hyaenidae, Ursidae, Viveridae, Felidae, Tayassuidae, and Cercopithecidae families. A combined strategy that involved the direct sequencing of amplicons from genes coding for nucleocapsid, large polymerase, and hemagglutinin proteins of CDV, as well as the pathological findings and the immunohistochemical detection of viral nucleocapsid protein in diverse tissues, confirmed the participation of CDV in the development of a neurological disease in a southern tamandua ( Tamandua tetradactyla ) from Midwestern Brazil. Phylogenetic analysis based on the hemagglutinin gene sequences revealed that the strain from this study grouped with isolates from the Europe 1/South America 1 lineage. The specific polymorphisms at the SLAM receptor-binding site of the hemagglutinin gene, previously linked to disease emergence in novel hosts, were not detected in this genome. These findings represent the first description of CDV-induced infection in the Tamandua tetradactyla and extend the distribution of this infection to include members of the family Myrmecophagidae, order Pilosa.
- Published
- 2018