Search

B Background b Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Based on the demonstration that TSLP is the linking factor between the environmental stimuli and the type of immune response, it is hypothesized herein that the expression of equine TSLP is upregulated in primary equine keratinocytes by Toll-like receptor (TLR) ligands (TLR-L). Finally, it was investigated whether allergic inflammation cytokine milieu (IL-4 and TNF- ) induces TSLP expression in keratinocytes from nonallergic horses and acts synergistically with TLR-1/2 and TLR-3-induced TSLP expression. These synergistic effects of the atopic cytokine milieu and TLR-L on TSLP expression also have been described in human: TLR-L Poly (I:C), FSL-1 and flagellin-induced TSLP expression, and, additionally, when combined with allergic inflammation cytokine milieu, these TLR-L synergistically further upregulate TSLP expression. [Extracted from the article]