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Measurements of parathyroid hormone concentrations were made in the serum of patients with vestibular larynx before treatment, after radiation treatment and after radiation treatment followed by surgery. Patients with laryngeal cancer were found to have impaired calcium metabolism, their serum parathyroid hormone concentrations were elevated. After radiotherapy, in a favorable clinical course, patients with cancer of the vestibular larynx stage II show normalization of the hormone levels, whereas the above combined treatment diminished the concentrations, but they still remain above normal.

Radioimmunoassay was employed to investigate time course changes in blood serum aldosteron in 28 patients with cancer of the middle laryngeal part before and after radiation treatment as well as after radiation treatment followed by surgical intervention. Initial values of aldosteron were low evidencing impaired mineral-corticoid activity of the adrenal cortex. Aldosteron returned to normal after effective radiotherapy at early tumor stage and after radical surgical treatment at later cancer stages. Hormonal unbalance provides more significant information on tumor involvement of the larynx and is a good indicator of the treatment efficiency.

Enzyme immunoassay was used to measure serum levels of hydrocortisone and aldosterone in 85 patients with vestibular laryngeal cancer before treatment and after it. The treatment consisted of either radiation alone or radiation followed by surgery. Pretreatment examination revealed adrenal dysfunction evident from enhanced glucocorticoid and inhibited mineral corticoid activity. Radiotherapy alone or in combination with surgery gave rise to a trend to a decline in glucocorticoid activity and stimulated mineral corticoid activity.