1. Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance
- Author
-
McDermott, Mary M, Peterson, Charlotte A, Sufit, Robert, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Polonsky, Tamar S, Tian, Lu, Criqui, Michael H, Zhao, Lihui, Stein, James H, Li, Lingyu, and Leeuwenburgh, Christiaan
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Cardiovascular ,Aging ,Genetics ,Clinical Research ,Aged ,Ankle Brachial Index ,Biopsy ,Case-Control Studies ,Cross-Sectional Studies ,DNA Copy Number Variations ,DNA ,Mitochondrial ,Exercise Tolerance ,Female ,Humans ,Lower Extremity ,Male ,Mitochondria ,Muscle ,Muscle ,Skeletal ,Peripheral Arterial Disease ,Randomized Controlled Trials as Topic ,Walk Test ,functional performance ,mitochondria ,peripheral artery disease ,vascular medicine ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
In people without lower extremity peripheral artery disease (PAD), mitochondrial DNA copy number declines with aging, and this decline is associated with declines in mitochondrial activity and functional performance. However, whether lower extremity ischemia is associated with lower mitochondrial DNA copy number and whether mitochondrial DNA copy number is associated with the degree of functional impairment in people with PAD is unknown. In people with and without PAD, age 65 years and older, we studied associations of the ankle-brachial index (ABI) with mitochondrial DNA copy number and associations of mitochondrial DNA copy number with functional impairment. Calf muscle biopsies were obtained from 34 participants with PAD (mean age: 73.5 years (SD 6.4), mean ABI: 0.67 (SD 0.15), mean 6-minute walk distance: 1191 feet (SD 223)) and 10 controls without PAD (mean age: 73.1 years (SD 4.7), mean ABI: 1.14 (SD 0.07), mean 6-minute walk distance: 1387 feet (SD 488)). Adjusting for age and sex, lower ABI values were associated with higher mitochondrial DNA copy number, measured in relative copy number (ABI
- Published
- 2018