1. One-Year Post-Vaccination Longitudinal Follow-Up of Quantitative SARS-CoV-2 Anti-Spike Total Antibodies in Health Care Professionals and Evaluation of Correlation with Surrogate Neutralization Test
- Author
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Yesim Tuyji Tok, Rabia Can Sarinoglu, Seyhan Ordekci, Serife Yilmaz, Gunes Ozcolpan, Aysen Bayram, Okan Kadir Nohut, Ipek Kocer, Ufuk Hasdemir, Mert Ahmet Kuskucu, Dildar Konukoglu, Aysegul Gozalan, Kenan Midilli, Gulden Celik, and Tuyji Tok Y., Can Sarinoglu R., Ordekci S., Yilmaz S., Ozcolpan G., Bayram A., NOHUT O. K., Kocer I., HASDEMİR GÖKBOĞA M. U., Kuskucu M. A., et al.
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mRNA ,Farmakoloji ,Immunology ,Life Sciences (LIFE) ,Molecular Biology and Genetics ,Sağlık Bilimleri ,heterologous ,BİYOKİMYA VE MOLEKÜLER BİYOLOJİ ,vaccine ,Yaşam Bilimleri ,Health Sciences ,Drug Discovery ,FARMAKOLOJİ VE ECZACILIK ,Pharmacology (medical) ,Cytogenetic ,Eczacılık ,PHARMACOLOGY & PHARMACY ,Moleküler Biyoloji ve Genetik ,Pharmacology ,PHARMACOLOGY & TOXICOLOGY ,İlaç Keşfi ,İmmünoloji ,inactivated ,Temel Bilimler ,Basic Pharmaceutics Sciences ,Life Sciences ,COVID-19 ,Pharmacology and Therapeutics ,Bulaşıcı hastalıklar ,Farmakoloji (tıbbi) ,MOLECULAR BIOLOGY & GENETICS ,Infectious Diseases ,Temel Eczacılık Bilimleri ,Yaşam Bilimleri (LIFE) ,BULAŞICI HASTALIKLAR ,Farmakoloji ve Toksikoloji ,Natural Sciences ,BIOCHEMISTRY & MOLECULAR BIOLOGY ,Sitogenetik - Abstract
Numerous vaccines have been generated to decrease the morbidity and mortality of COVID-19. This study aims to evaluate the immunogenicity of the heterologous boosts by BioNTech against homologous boosts by CoronaVac at three-month intervals in two health care worker (HCW) cohorts, with or without prior COVID-19, for one year post-vaccination. This is a prospective cohort study in which the humoral responses of 386 HCWs were followed-up longitudinally in six main groups according to their previous COVID-19 exposure and vaccination status. Anti-SARS-CoV-2 spike-RBD total antibody levels were measured and SARS-CoV-2 neutralization antibody (NAbs) responses against the ancestral Wuhan and the Omicron variant were evaluated comparatively using international standard serum for Wuhan and Omicron, as well as with the aid of a conversion tool. The anti-SARS-CoV-2 spike-RBD total Ab and Nab difference between with and without prior COVID-19, three months after two-dose primary vaccination with CoronaVac, was statistically significant (p = 0.001). In the subsequent follow-ups, this difference was not observed between the groups. Those previously infected (PI) and non-previously infected (NPI) groups receiving BioNTech as the third dose had higher anti-SARS-CoV-2 spike total Ab levels (14.2-fold and 17.4-fold, respectively, p = 0.001) and Nab responses (against Wuhan and Omicron) than those receiving CoronaVac. Ab responses after booster vaccination decreased significantly in all groups at the ninth-month follow-up (p < 0.05); however, Abs were still higher in all booster received groups than that in the primary vaccination. Abs were above the protective level at the twelfth-month measurement in the entire of the second BioNTech received group as the fourth dose of vaccination. In the one-year follow-up period, the increased incidence of COVID-19 in the groups vaccinated with two or three doses of CoronaVac compared with the groups vaccinated with BioNTech as a booster suggested that continuing the heterologous CoronaVac/BioNTech vaccination, revised according to current SARS-CoV-2 variants and with at least a six-month interval booster would be an effective and safe strategy for protection against COVID-19, particularly in health care workers.
- Published
- 2023
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