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4 results on '"Brunelli Brunella"'

1. Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines

Author

Oldrini, Davide, primary, Di Benedetto, Roberta, additional, Carducci, Martina, additional, De Simone, Daniele, additional, Massai, Luisa, additional, Alfini, Renzo, additional, Galli, Barbara, additional, Brunelli, Brunella, additional, Przedpelski, Amanda, additional, Barbieri, Joseph T., additional, Rossi, Omar, additional, Giannelli, Carlo, additional, Rappuoli, Rino, additional, Berti, Francesco, additional, and Micoli, Francesca, additional

Published
2023
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2. Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching.

Author

Piccioli, Diego, Buricchi, Francesca, Bacconi, Marta, Bechi, Nicoletta, Galli, Barbara, Ferlicca, Francesca, Luzzi, Enrico, Cartocci, Elena, Marchi, Sara, Romagnoli, Giacomo, Alfini, Renzo, Di Benedetto, Roberta, Gallorini, Simona, Savino, Silvana, Brunelli, Brunella, Bartolini, Erika, and Micoli, Francesca

Subjects
HUMORAL immunity, IMMUNOGLOBULIN class switching, EXTRACELLULAR vesicles, ANTIGENS, CELL surface antigens
Abstract

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a potent humoral immune response in preclinical and clinical studies. In addition, in preclinical studies, it has been found that GMMA can be exploited as optimal antigen carriers for both protein and saccharide antigens, as they are able to promote the enhancement of the antigen-specific humoral immune response when the antigen is overexpressed or chemically conjugated to GMMA. Here we investigated the mechanism of this GMMA carrier effect by immunizing mice and using factor H binding protein and GMMA of Neisseria meningitidis B as an antigen–GMMA model. We confirmed that the antigen displayed on the GMMA surface increased the antigen-specific IgG production and, above all, the antibody functionality measured by the serum bactericidal activity. We found that the enhancement of the bactericidal capacity induced by GMMA carrying the antigen on the surface was associated with the increase in antibody affinity to the antigen, and with the switching toward IgG subclasses with more bactericidal potential. Thus, we conclude that the potent carrier effect of GMMA is due to their ability to promote a better quality of humoral immunity. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Investigating the Role of Antigen Orientation on the Immune Response Elicited by Neisseria meningitidis Factor H Binding Protein on GMMA

Author

Alfini, Renzo, primary, Brunelli, Brunella, additional, Bartolini, Erika, additional, Carducci, Martina, additional, Luzzi, Enrico, additional, Ferlicca, Francesca, additional, Buccato, Scilla, additional, Galli, Barbara, additional, Lo Surdo, Paola, additional, Scarselli, Maria, additional, Romagnoli, Giacomo, additional, Cartocci, Elena, additional, Maione, Domenico, additional, Savino, Silvana, additional, Necchi, Francesca, additional, Delany, Isabel, additional, and Micoli, Francesca, additional

Published
2022
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4. GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines

Author

Micoli, Francesca, primary, Alfini, Renzo, additional, Di Benedetto, Roberta, additional, Necchi, Francesca, additional, Schiavo, Fabiola, additional, Mancini, Francesca, additional, Carducci, Martina, additional, Palmieri, Elena, additional, Balocchi, Cristiana, additional, Gasperini, Gianmarco, additional, Brunelli, Brunella, additional, Costantino, Paolo, additional, Adamo, Roberto, additional, Piccioli, Diego, additional, and Saul, Allan, additional

Published
2020
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