1. Effect of pneumococcal conjugate vaccine on prevalence of otitis media with effusion among children in Vietnam
- Author
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Michiko Toizumi, Chisei Satoh, Billy J. Quilty, Hien Anh Thi Nguyen, Lina Madaniyazi, Lien Thuy Le, Chris Fook Sheng Ng, Minoru Hara, Chihiro Iwasaki, Mizuki Takegata, Noriko Kitamura, Monica Larissa Nation, Catherine Satzke, Yoshihiko Kumai, Hung Thai Do, Minh Xuan Bui, Kim Mulholland, Stefan Flasche, Duc Anh Dang, Kenichi Kaneko, and Lay-Myint Yoshida
- Subjects
Vaccines, Conjugate ,General Veterinary ,General Immunology and Microbiology ,Otitis Media with Effusion ,Public Health, Environmental and Occupational Health ,Infant ,Pneumococcal Infections ,Pneumococcal Vaccines ,Otitis Media ,Cross-Sectional Studies ,Streptococcus pneumoniae ,Infectious Diseases ,Vietnam ,Nasopharynx ,Carrier State ,Prevalence ,Humans ,Molecular Medicine - Abstract
PURPOSE: Otitis media with effusion (OME) is common in young children and is associated with Streptococcus pneumoniae infection. We aimed to determine the impact of pneumococcal conjugate vaccine (PCV) introduction on the prevalence of OME and OME associated with vaccine-type (VT) or non-VT. METHODS: Population-based cross-sectional surveys were conducted in pre- (2016) and post-PCV periods (2017, 2018, and 2019) at selected communes in Nha Trang, Vietnam. For each survey, we randomly selected 60 children aged 4-11 months and 60 aged 14-23 months from each commune. Nasopharyngeal sample collection and tympanic membrane examination by digital otoscope were performed. S. pneumoniae was detected and serotyped by lytA qPCR and microarray. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using Firth's logistic regression, stratified by age group. RESULTS: Over the four surveys, 2089 children had a bilateral ear examination. Compared to pre-PCV, the prevalence of OME reduced in 2018 (OR 0.51, 95 %CI 0.28-0.93) and in 2019 (OR 0.53, 95 %CI 0.29-0.97) among the
- Published
- 2022