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2. The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004–2014

Author

Kanitz, Elisabeth, Richter, Lukas, Mattheus, Wesley, Bleyenheuft, Corinne, Georgieva, Teodora, Simeonovski, Ivan, Vučina, Vesna Višekruna, Filipović, Sanja Kurečić, Koliou, Maria, Bagatzouni, Despo Pieridou, Krizova, Pavla, Sebestova, Helena, Hoffmann, Steen, Valentiner-Branth, Palle, Kerbo, Natalia, Peetso, Rita, Kuusi, Markku, Toropainen, Maija, Parent, Isabelle, Taha, Muhamed-Kheir, Vogel, Ulrich, Hellenbrand, Wiebke, Georgakopoulou, Theano, Tzanakaki, Georgina, Krisztalovics, Katalin, Tirczka, Tamás, Gudnason, Thorolfur, Hardardottir, Hjordis, O'Lorcain, Piaras, Bennett, Desiree, D'Ancona, Fortunato, Stefanelli, Paola, Savrasova, Larissa, Vasilevska, Darja, Kuprevičienė, Nerija, Liausedienė, Rasa, Demuth, Irène, Scheiden, Gérard, Melillo, Jackie Maistre, Caruana, Paul, van der Ende, Arie, Mollema, Liesbeth, Caugant, Dominique, Blystad, Hans, Skoczyńska, Anna, Zota, Lavinia, Pana, Marina, Grgič Vitek, Marta, Paragi, Metka, Cano, Rosa, Abad, Raquel, Lepp, Tiia, Campbell, Helen, Whittaker, Robert, Dias, Joana Gomes, Ramliden, Miriam, Ködmön, Csaba, Economopoulou, Assimoula, Beer, Netta, and Pastore Celentano, Lucia

Published
2017
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4. Impact of pneumococcal vaccination in Denmark during the first 3 years after PCV introduction in the childhood immunization programme

Author

Ingels, Helene, Rasmussen, Jeppe, Andersen, Peter Henrik, Harboe, Zitta B, Glismann, Steffen, Konradsen, Helle, Hoffmann, Steen, Valentiner-Branth, Palle, Lambertsen, Lotte, and Schønheyder, Henrik Carl

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Heptavalent Pneumococcal Conjugate Vaccine, Adolescent, Denmark, Population, Rate ratio, medicine.disease_cause, complex mixtures, Pneumococcal Infections, Pneumococcal conjugate vaccine, Pneumococcal Vaccines, Young Adult, Streptococcus pneumoniae, Case fatality rate, medicine, Humans, Serotyping, Child, education, Aged, Aged, 80 and over, education.field_of_study, General Veterinary, General Immunology and Microbiology, Immunization Programs, business.industry, Incidence, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Infant, Middle Aged, bacterial infections and mycoses, medicine.disease, Confidence interval, Pneumococcal infections, Infectious Diseases, Child, Preschool, Molecular Medicine, Female, business, medicine.drug
Abstract

Background and aims The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in Denmark in October 2007 in a 2 + 1 schedule with a catch-up programme for children up to 17 months of age. To assess the impact of PCV we evaluated on the whole population: (1) direct and indirect effects on incidence of invasive pneumococcal disease (IPD), (2) changes in pneumococcal serotype distribution and (3) IPD related mortality. Methods We compared disease incidence in pre-PCV (years 2000–2007) and PCV periods (years 2008–2010) based on national surveillance data. Results In children aged 0–5 years the overall incidence of IPD decreased from 26.7 to 16.3 cases per 100,000 (IRR 0.58; 95% Confidence Interval (CI) [0.48–0.69]) and case fatality declined from 1.8% (12 deaths) in the eight-year pre-PCV period to 0% (no deaths) in the three-year PCV period. In the whole population the overall incidence of IPD and of IPD caused by vaccine serotypes declined significantly from 19.5 to 17.7 and from 7.7 to 3.8 cases per 100,000 persons comparing the two periods. The incidence of IPD due to non-vaccine serotypes (NVT-IPD) increased significantly from 11.8 to 13.9 cases per 100,000 in the whole population (incidence rate ratio 1.18; 95% CI [1.12–1.24]) with predominance of the serotypes 1.7F and 19A. Conclusions We report a marked decline in incidence in IPD in both vaccinated and non-vaccinated age groups and a minor but statistically significant increase in incidence of IPD due to NVTs in both vaccinated and non-vaccinated groups with predominance of serotypes covered by higher valence pneumococcal conjugate vaccines.

Published
2012
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5. The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004–2014

Author

Whittaker, Robert, primary, Dias, Joana Gomes, additional, Ramliden, Miriam, additional, Ködmön, Csaba, additional, Economopoulou, Assimoula, additional, Beer, Netta, additional, Pastore Celentano, Lucia, additional, Kanitz, Elisabeth, additional, Richter, Lukas, additional, Mattheus, Wesley, additional, Bleyenheuft, Corinne, additional, Georgieva, Teodora, additional, Simeonovski, Ivan, additional, Vučina, Vesna Višekruna, additional, Filipović, Sanja Kurečić, additional, Koliou, Maria, additional, Bagatzouni, Despo Pieridou, additional, Krizova, Pavla, additional, Sebestova, Helena, additional, Hoffmann, Steen, additional, Valentiner-Branth, Palle, additional, Kerbo, Natalia, additional, Peetso, Rita, additional, Kuusi, Markku, additional, Toropainen, Maija, additional, Parent, Isabelle, additional, Taha, Muhamed-Kheir, additional, Vogel, Ulrich, additional, Hellenbrand, Wiebke, additional, Georgakopoulou, Theano, additional, Tzanakaki, Georgina, additional, Krisztalovics, Katalin, additional, Tirczka, Tamás, additional, Gudnason, Thorolfur, additional, Hardardottir, Hjordis, additional, O'Lorcain, Piaras, additional, Bennett, Desiree, additional, D'Ancona, Fortunato, additional, Stefanelli, Paola, additional, Savrasova, Larissa, additional, Vasilevska, Darja, additional, Kuprevičienė, Nerija, additional, Liausedienė, Rasa, additional, Demuth, Irène, additional, Scheiden, Gérard, additional, Melillo, Jackie Maistre, additional, Caruana, Paul, additional, van der Ende, Arie, additional, Mollema, Liesbeth, additional, Caugant, Dominique, additional, Blystad, Hans, additional, Skoczyńska, Anna, additional, Zota, Lavinia, additional, Pana, Marina, additional, Grgič Vitek, Marta, additional, Paragi, Metka, additional, Cano, Rosa, additional, Abad, Raquel, additional, Lepp, Tiia, additional, and Campbell, Helen, additional

Published
2017
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