1. The role of BCG in human immune responses induced by multiple injections of autoclaved Leishmania major as a candidate vaccine against leishmaniasis
- Author
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Alireza Firooz, Mohammad Hossein Alimohammadian, Haiedeh Darabi, Ali Khamesipour, Shirin Malekzadeh, Farrokh Modabber, Ahmad Bahonar, and Yahya Dowlati
- Subjects
Adult ,Male ,Protozoan Vaccines ,Tuberculosis ,Adolescent ,complex mixtures ,Interferon-gamma ,Immune system ,Double-Blind Method ,medicine ,Animals ,Humans ,Leishmania major ,Adverse effect ,Leishmaniasis ,Leishmaniasis Vaccines ,Mycobacterium bovis ,General Veterinary ,General Immunology and Microbiology ,biology ,Vaccination ,fungi ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,biology.organism_classification ,Virology ,Infectious Diseases ,Vaccines, Inactivated ,Immunology ,BCG Vaccine ,Molecular Medicine ,Drug Therapy, Combination ,Female - Abstract
To determine if BCG was required in booster injections for autoclaved Leishmania major (ALM) vaccine, 75 volunteers with no response to leishmanin were injected double-blind and randomly with either ALM+BCG or BCG alone for the first injection and boosted either with ALM+BCG, ALM or BCG alone for the second and third. Addition of BCG to the boosters significantly increased the frequency and the magnitude of leishmanin skin tests (LSTs); however, there was no difference in proliferative and IFN-gamma responses (a month and a year later). Three injections of BCG produced no observable adverse reaction; hence BCG could be used in booster injections to increase the protective potential of this candidate vaccine.
- Published
- 2002
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