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1. Evaluation of the national immunisation programme in the Netherlands: immunity to diphtheria, tetanus, poliomyelitis, measles, mumps, rubella and type b

Author

G. A. M. Berbers, H.E. de Melker, S. van den Hof, and M. A. E. Conyn-Van Spaendonck

Subjects
education.field_of_study, Pediatrics, medicine.medical_specialty, General Veterinary, General Immunology and Microbiology, Tetanus, business.industry, Diphtheria, Population, Public Health, Environmental and Occupational Health, medicine.disease, Rubella, Measles, Herd immunity, Vaccination, Infectious Diseases, Immunology, medicine, Molecular Medicine, Vaccine-preventable diseases, education, business
Abstract

The immunity to vaccine-preventable diseases included in the Dutch immunisation programme in the general population and among orthodox reformed individuals who refuse vaccination was assessed. The programme induces good protection. However, a large proportion of adults lacks diphtheria and tetanus immunity. Measles, mumps and rubella seroprevalence was somewhat lower among vaccinated compared to unvaccinated cohorts. The prevalence of HibPS antibodies declined during 2.5 years after the fourth vaccination. However, protection occurs also by memory immunity. Herd immunity is sufficient among the general population, but not among orthodox reformed individuals. Immunosurveillance is an efficient way to evaluate the effects of immunisation programmes and identify risk groups for infection.

Published
2003
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2. A population-based study on tetanus antitoxin levels in the Netherlands

Author

H.C. Rümke, G. A. M. Berbers, S. van den Hof, H.E. de Melker, Nico J. D. Nagelkerke, and M. A. E. Conyn-Van Spaendonck

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Adolescent, Population, Tetanus Antitoxin, complex mixtures, Sex Factors, Immunity, Tetanus Toxoid, Humans, Medicine, Routine vaccination, Child, education, Netherlands, education.field_of_study, General Veterinary, General Immunology and Microbiology, business.industry, Tetanus, Public health, Vaccination, Age Factors, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Tetanus antitoxin, Middle Aged, medicine.disease, Population based study, Infectious Diseases, Child, Preschool, Immunology, Molecular Medicine, Female, business
Abstract

We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protective level. After the sixth vaccination, a fall in tetanus antitoxin levels occurred. Nevertheless, immunisation in accordance with the routine programme most likely induces protection for much longer than two decades. Not only many members of religious groups who refuse vaccination, but also many adults born before the introduction of vaccination lack tetanus immunity. These cohorts might benefit most from (re)vaccination.

Published
1999
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3. Evaluation of the national immunisation programme in the Netherlands: immunity to diphtheria, tetanus, poliomyelitis, measles, mumps, rubella and Haemophilus influenzae type b

Author

H E, de Melker, S, van den Hof, G A M, Berbers, and M A E, Conyn-van Spaendonck

Subjects
Adult, Haemophilus Infections, Tetanus, Adolescent, National Health Programs, Immunization Programs, Haemophilus influenzae type b, Infant, Newborn, Infant, Diphtheria, Middle Aged, Communicable Diseases, Mass Vaccination, Child, Preschool, Communicable Disease Control, Humans, Child, Mumps, Rubella, Aged, Measles, Netherlands, Poliomyelitis, Program Evaluation
Abstract

The immunity to vaccine-preventable diseases included in the Dutch immunisation programme in the general population and among orthodox reformed individuals who refuse vaccination was assessed. The programme induces good protection. However, a large proportion of adults lacks diphtheria and tetanus immunity. Measles, mumps and rubella seroprevalence was somewhat lower among vaccinated compared to unvaccinated cohorts. The prevalence of HibPS antibodies declined during 2.5 years after the fourth vaccination. However, protection occurs also by memory immunity. Herd immunity is sufficient among the general population, but not among orthodox reformed individuals. Immunosurveillance is an efficient way to evaluate the effects of immunisation programmes and identify risk groups for infection.

Published
2003

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