1. Enhanced decision support for policy makers using a web interface to health-economic models—Illustrated with a cost-effectiveness analysis of nation-wide infant vaccination with the 7-valent pneumococcal conjugate vaccine in the Netherlands
- Author
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Maarten J. Postma, Diarmuid M. Glynn, L van Alphen, A. van der Ende, G. A. A. Hubben, JM Bos, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Science in Healthy Ageing & healthcaRE (SHARE), and Methods in Medicines evaluation & Outcomes research (M2O)
- Subjects
BACTERIAL-MENINGITIS ,PNEUMONIA ,Immunity, Herd ,Decision support system ,Pediatrics ,Heptavalent Pneumococcal Conjugate Vaccine ,Cost effectiveness ,Cost-Benefit Analysis ,ENGLAND ,CHILDREN ,Bacteremia ,IMMUNOGENICITY ,DISEASE ,Pneumococcal conjugate vaccine ,Pneumococcal Vaccines ,WALES ,EPIDEMIOLOGY ,Medicine ,Netherlands ,cost effectiveness ,Cost–benefit analysis ,Meningitis, Pneumococcal ,Health Policy ,Vaccination ,Cost-effectiveness analysis ,Models, Economic ,Infectious Diseases ,web interface for policy decision support ,Molecular Medicine ,medicine.drug ,medicine.medical_specialty ,Meningococcal Vaccines ,pneumococcal conjugate vaccine PCV ,Pneumococcal Infections ,Environmental health ,Humans ,Internet ,General Veterinary ,General Immunology and Microbiology ,Immunization Programs ,business.industry ,Decision Trees ,Public Health, Environmental and Occupational Health ,Infant ,Pneumonia, Pneumococcal ,PREVENTION ,Quality-adjusted life year ,business - Abstract
We have developed a web-based user-interface (web interface) to enhance the usefulness of health-economic evaluations to support decision making (http://pcv.healtheconomics.nl). It allows the user to interact with a health-economic model to evaluate predefined and customized scenarios and perform sensitivity analysis. To explore its usefulness, it was applied to an evaluation of cost-effectiveness of nation-wide infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7), that was used to support a policy decision on the inclusion of PCV7 in the national vaccination program (NVP) of the Netherlands. We used a decision-tree analytic model to project the impact of infant vaccination with four doses of PCV7 on an annual cohort of infants born in the Netherlands. The base-case analysis includes the beneficial effects on unvaccinated individuals (herd protection). Additional scenarios varying the number of doses, discount rate for effects and the number of serotypes in the vaccine were evaluated and can be analysed on the web. Our model projects a base-case incremental cost-effectiveness ratio (iCER) of epsilon 14,000 (95% uncertainty interval (UI): 9,800-20,200) per quality adjusted life year (QALY) or epsilon 15,600 (95% UI: 11,100-23,900) per life year gained (LYG). (C) 2007 Elsevier Ltd. All rights reserved.
- Published
- 2007