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Your search keyword '"Duthie, Malcolm S."' showing total 12 results
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12 results on '"Duthie, Malcolm S."'

7. A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA–SE) in healthy adults

Author

Duthie, Malcolm S., primary, Frevol, Aude, additional, Day, Tracey, additional, Coler, Rhea N., additional, Vergara, Julie, additional, Rolf, Tom, additional, Sagawa, Zachary K., additional, Marie Beckmann, Anna, additional, Casper, Corey, additional, and Reed, Steven G., additional

Published
2020
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11. Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

Author

Baldwin, Susan L., primary, Shaverdian, Narek, additional, Goto, Yasuyuki, additional, Duthie, Malcolm S., additional, Raman, Vanitha S., additional, Evers, Tara, additional, Mompoint, Farah, additional, Vedvick, Thomas S., additional, Bertholet, Sylvie, additional, Coler, Rhea N., additional, and Reed, Steven G., additional

Published
2009
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12. Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

Author

Baldwin, Susan L., Shaverdian, Narek, Goto, Yasuyuki, Duthie, Malcolm S., Raman, Vanitha S., Evers, Tara, Mompoint, Farah, Vedvick, Thomas S., Bertholet, Sylvie, Coler, Rhea N., and Reed, Steven G.

Subjects
*INFLUENZA vaccines, *IMMUNE response, *CELLULAR immunity, *ANTIVIRAL agents, *IMMUNOLOGICAL adjuvants, *MORTALITY, *IMMUNOGLOBULIN G, *BLOOD agglutination, *TH1 cells
Abstract

Abstract: Impairments in anti-influenza T helper 1 (Th1) responses are associated with greater risk of influenza-related mortality in the elderly. Addition of adjuvants to existing influenza vaccines could improve immune responses in the elderly. In this study, the activity of three adjuvants, an oil-in-water emulsion and a synthetic lipid A adjuvant formulated with or without the emulsion, is compared. Our results show that Fluzone combined with lipid A plus an emulsion effectively leads to greater vaccine-specific IgG2a and IgG titers, enhances hemagglutination-inhibition titers and induces Type 1 cytokine responses (IFN-γ and IL-2) to each of the Fluzone components. [Copyright &y& Elsevier]

Published
2009
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