1. Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys
- Author
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David Brown, D. James Nokes, Phillippa M. Cumberland, Eshetu Lemma, Dhan Samuel, W. Nigatu, and Bernard J. Cohen
- Subjects
Adult ,Adolescent ,Measles Vaccine ,Antibodies, Viral ,Mass Vaccination ,Measles ,Rubella ,Environmental health ,medicine ,Humans ,Seroprevalence ,Child ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Transmission (medicine) ,Mouth Mucosa ,Public Health, Environmental and Occupational Health ,Infant ,medicine.disease ,Vaccination ,Infectious Diseases ,Immunization ,Child, Preschool ,Immunoglobulin G ,Immunology ,Molecular Medicine ,Ethiopia ,Measles vaccine ,Viral disease ,business - Abstract
We undertook a study to demonstrate the potential contribution of oral-fluid (OF) antibody prevalence surveys in evaluating measles vaccine campaigns. In Asela town, southern Ethiopia, oral fluids were collected from 1928 children aged 9 months to 5 years attending for campaign immunization in December 1999 and 6 months later, from 745 individuals aged 9 months to 19 years, in the same location. Measles antibody status was determined by microimmune measles specific IgG enzyme immunoassay (EIA). Antibody prevalence was estimated at 48% in children attending for vaccination (pre-campaign), and 85% post-campaign in the comparable age group. The estimated reduction in the susceptible proportion was 75%. In older children the proportion antibody negative post-campaign was 28% in 7-9 year olds, and 13% in 10-14 year olds levels of susceptibility which raise concern over continued measles transmission. This is the first evaluation of a measles vaccine campaign based on oral-fluid seroprevalence surveys and it demonstrates the merit of oral-fluid surveys in informing health authorities about vaccination strategy refinement.
- Published
- 2008
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