1. Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995–2009
- Author
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Ho, Pak-Leung, Chiu, Susan S., Ang, Irene, and Lau, Yu-Lung
- Subjects
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STREPTOCOCCUS pneumoniae , *SEROTYPES , *ANTI-infective agents , *MICROBIAL sensitivity tests , *PNEUMOCOCCAL vaccines , *DRUG resistance in microorganisms , *ERYTHROMYCIN , *MEDICAL statistics - Abstract
Abstract: This study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995–2001, n =265) and after (2007–2009, n =563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36–15.7%, P <0.01) while 19A had increased (0–12.9%, P <0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4–93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P =0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P =0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P =0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. [Copyright &y& Elsevier]
- Published
- 2011
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