1. Mucosal immunization with dual influenza/COVID-19 single-replication virus vector protects hamsters from SARS-CoV-2 challenge.
- Author
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Hill-Batorski L, Bowen R, Bielefeldt-Ohmann H, Moser MJ, Matejka SM, Marshall D, Kawaoka Y, Neumann G, and Bilsel P
- Subjects
- Humans, Cricetinae, COVID-19 Vaccines, SARS-CoV-2, Influenza A Virus, H3N2 Subtype, Pandemics prevention & control, Antibodies, Viral, Vaccination, Antibodies, Neutralizing, Adjuvants, Immunologic, Influenza, Human prevention & control, Influenza Vaccines, Orthomyxoviridae Infections prevention & control, COVID-19 prevention & control
- Abstract
The COVID-19 pandemic has highlighted the need for mucosal vaccines as breakthrough infections, short-lived immune responses and emergence of new variants have challenged the efficacy provided by the first generation of vaccines against SARS-CoV-2 viruses. M2SR SARS-CoV-2, an M2-deleted single-replication influenza virus vector modified to encode the SARS-CoV-2 receptor binding domain, was evaluated following intranasal delivery in a hamster challenge model for protection against Wuhan SARS-CoV-2. An adjuvanted inactivated SARS-CoV-2 whole virus vaccine administered intramuscularly was also evaluated. The intranasal M2SR SARS-CoV-2 was more effective than the intramuscular adjuvanted inactivated whole virus vaccine in providing protection against SARS-CoV-2 challenge. M2SR SARS-CoV-2 elicited neutralizing serum antibodies against Wuhan and Omicron SARS-CoV-2 viruses in addition to cross-reactive mucosal antibodies. Furthermore, M2SR SARS-CoV-2 generated serum HAI and mucosal antibody responses against influenza similar to an H3N2 M2SR influenza vaccine. The intranasal dual influenza/COVID M2SR SARS-CoV-2 vaccine has the potential to provide protection against both influenza and COVID., Competing Interests: Declaration of competing interest R.B. and H.B-O. have no conflict of interest. G.N. and Y.K. are the founders of FluGen. L.H., M.M., D.M., S.M. and P.B. are employees of FluGen., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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