1. Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy
- Author
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Ikeda, Tomohiro, Tanaka, Nobumichi, Shimada, Keiji, Matsumura, Yoshiaki, Miyake, Makito, Anai, Satoshi, Tomioka, Atsushi, Okajima, Eijiro, Hirayama, Akihide, Fujimoto, Kiyohide, Konishi, Noboru, and Hirao, Yoshihiko
- Subjects
p-FADD ,Prostate cancer ,biochemical recurrence ,biological phenomena, cell phenomena, and immunity ,urologic and male genital diseases ,prognostic factor ,radical prostatectomy - Abstract
OBJECTIVE: To assess whether the phosphorylated Fas-associated death domain protein (FADD) at 194 serine (p-FADD) is valuable as a marker of biochemical recurrence in hormone-naive patients who had undergone radical prostatectomy. MATERIALS AND METHODS: We used radical prostatectomy specimens from 106 patients. None of the patients had received neoadjuvant or adjuvant therapy. The percentage of positive p-FADD cells (nuclear staining) was immunohistochemically evaluated. The correlation between FADD phosphorylation and the clinicopathologic parameters was assessed. The correlation between the biochemical recurrence-free rate and the p-FADD expression level was analyzed using the Kaplan-Meier method. RESULTS: Overall, 39 patients developed biochemical recurrence. We investigated the expression of p-FADD in 106 patients with prostate cancer using immunohistochemistry. We compared our findings with the clinicopathologic parameters, including the follow-up data. Patients with a greater positive p-FADD rate had a significantly lower biochemical recurrence rate than those with a lower positive p-FADD rate (P < .001). A significant inverse correlation was found between the positive p-FADD rate and the Gleason score. CONCLUSION: A low expression of p-FADD could be a predictor of biochemical recurrence in hormone-naive patients who have undergone radical prostatectomy., 博士（医学）・乙第1313号・平成25年5月29日
- Published
- 2013