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A retrospective multicenter trial with participation of 7 large clinics of Moscow and Moscow Region has been performed to characterize complications after correction of genital prolapse with application of the PROLIFT system. The trial enrolled women with uterine and vaginal prolapse of stage II-IV by POP-Q classification. The women also had anatomic and functional defects of the adjacent organs. From January 2005 to March 2008 all the patients have undergone vaginal extraperitoneal colpopexy using Prolift system. The results of the trial showed that extraperitoneal colpopexy with application of the Prolift system should not be considered as a low-invasive intervention and therefore it is not valid to use this technique as a routine method of genital prolapse treatment as in 29.5% cases the operation is accompanied with complications of different severity.

Urinary incontinence (UI) in patients with genital prolapse is not always related to stress. It may result from dyslocation of the vesicourethral segment. While genital prolapse in young patients after a single normal delivery is common manifestation of connective tissue dysplasia (CTD) at the level of the reproductive system, 51.8% cases of UI may be of neurogenic origin and present as dysfunction of the vesicourethral segment and pelvic diaphragm. Unstability of the bladder and urethra in these cases may represent CTD at the level of the pelvic organs.