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Patients suffering from renal cell carcinoma have a generally poor prognosis. Even cases that are clinically in comparable stages can, however, take quite different courses. The basic prognostic factors, histological grade and TNM stage do not do justice to the heterogeneous biological behavior of this tumor entity. In this study, the possible prognostic indicators, DNA content and proliferation rate, assessed with Ki-67, were compared with the histological grade and the TNM stage. Though there was no correlation between the proliferation rate (Ki-67) and the two, there was a significant correlation between DNA content and both histological grade and TNM stage.

We report on a case of primary melanoma within a diverticulum of the urinary bladder. The primary nature of this neoplasm was demonstrated through meticulous clinical and radiological examination. The incidence, prognosis and differential diagnosis of this urothelial melanoma are discussed.