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Treatment options in patients with prostate cancer (PCa) localized to the bones include the use of drugs making an attempt to improve their quality of life. In addition new therapies based on drugs with strong bone tropism have been developed. Samario 153 (Sm 153) is a radio-active compound that linked to a particular bifosfanate drug (EDTA) is able to reach and to bind to the bony-tessue carrying out its therapeutic effects. In this report we have analyzed the efficacy and the safety of a single treatment with Sm 153 in patients with metastatic bones spread of PCa causing a painful symptomatology.

Hydronephrosis during pregnancy is commonly considered physiological due to compression of the ureters by the gravid uterus and by dilated ovarian veins. Only in symptomatic cases or secondary to obstruction is a urinary diversion required. Six cases of symptomatic hydronephrosis treated with percutaneous nephrostomy are reported. Tocolytic therapy was practised in order to avoid the risk of abortion.