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This paper proposes a methodology for the optimal design of series of sewer pipes including pumping stations. It employs a Shortest Path Algorithm to select the optimal combination of pipe diameters and invert elevations, as well as the optimal pumping features such as the number of pumps, location, and pumping head. The methodology is intended to be applied to the design of any sewer series. Although these are uncommon in real infrastructure, the study allows an analysis of the effect of pipe roughness, inflows, and pipe length on the total cost of the system and pumping features. The methodology was tested in theoretical series of 10 and 20 pipes as well as in a real series that is part of the sewer system of Bogotá, Colombia. The resulting designs suggested that using smooth pipes and reducing the pumping flow rate would decrease the cost of sewer systems in flat terrain. [ABSTRACT FROM AUTHOR]