DUNE is a next-generation long-baseline neutrino oscillation experiment. It is expected to measure, with unprecedented precision, the atmospheric oscillation parameters, including the CP-violating phase δ C P . Moreover, several studies have suggested that its unique features should allow DUNE to probe several new physics scenarios. In this work, we explore the performances of the DUNE far detector in constraining new physics if a high-energy neutrino flux is employed (HE-DUNE). We take into account three different scenarios: Lorentz Invariance Violation (LIV), Long-Range Forces (LRFs) and Large Extra Dimensions (LEDs). Our results show that HE-DUNE should be able to set bounds competitive to the current ones and, in particular, it can outperform the standard DUNE capabilities in constraining CPT-even LIV parameters and the compactification radius R E D of the LED model. [ABSTRACT FROM AUTHOR]