1. Diagnostic Performance of 2-D Shear-Wave Elastography with Propagation Maps and Attenuation Imaging in Patients with Non-Alcoholic Fatty Liver Disease
- Author
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Victor Bâldea, Ioan Sporea, Frane Pastrovic, Tonci Bozin, Ivica Grgurević, Zeljko Puljiz, Alina Popescu, Tomislav Bokun, Nermin N. Salkic, Kristian Podrug, Raluca Lupusoru, Roxana Șirli, and Sanda Mustapic
- Subjects
Adult ,Male ,Acoustics and Ultrasonics ,Biophysics ,Non-alcoholic Fatty Liver Disease ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Prospective Studies ,Aged ,Shear wave elastography ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Attenuation ,liver fibrosis ,liver steatosis ,ultrasound-based elastography ,non-invasive methods ,diagnostic performance ,Fatty liver ,Middle Aged ,medicine.disease ,Elasticity Imaging Techniques ,Female ,Elastography ,Steatosis ,business ,Nuclear medicine ,Transient elastography ,Body mass index - Abstract
We aimed to investigate the diagnostic performance of new 2-D shear-wave elastography (SWE) with propagation maps and attenuation imaging (ATI) for quantification of fibrosis and steatosis in non- alcoholic fatty liver disease (NAFLD). Consecutive patients with NAFLD and healthy volunteers underwent liver stiffness measurement and steatosis quantification by means of vibration- controlled transient elastography coupled with the controlled attenuation parameter as the reference and by 2-D shear-wave elastography (2-D-SWE) with propagation maps and ATI as the investigational methods. We included 232 participants (164 in the NAFLD group and 68 in the healthy control group): 51.7%/49.3% women/men ; mean age, 54.2 +/- 15.2 y ; mean body mass index, 29.4 +/- 6.5 kg/m(2). Significant correlations were found between 2-D- SWE and vibration-controlled transient elastography (r = 0.71, p < 0.0001) and between ATI and the controlled attenuation parameter (r = 0.72, p < 0.0001). NAFLD-specific 2-D-SWE liver stiffness measurement cutoffs were as follows-F >= 2: 7.9 kPa (area under the curve [AUC] = 0.91) ; F >= 3: 10 kPa (AUC = 0.92) ; and F = 4: 11.4 kPa (AUC = 0.95). For steatosis, the best cutoffs by ATI were as follows-S1 = 0.73 dB/cm/MHz (AUC = 0.86) ; S2 = 0.76 dB/cm/MHz (AUC = 0.86) ; and S3 = 0.80 dB/cm/MHz (AUC = 0.83). According to Baveno VI criteria, the optimal 2-D-SWE liver stiffness measurement for diagnosing liver cirrhosis is 15.5 kPa (AUC = 0.94), and for ruling out compensated advanced chronic liver disease it is 9.2 kPa (AUC = 0.92). To conclude, 2-D-SWE with propagation maps and ATI is reliable for quantification of liver fibrosis and steatosis in patients with NAFLD.
- Published
- 2021
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