27 results on '"So-Hyun Yoon"'
Search Results
2. Hyalinizing trabecular tumor of the thyroid: diagnosis of a rare tumor using ultrasonography, cytology, and intraoperative frozen sections
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Hyunsik Jang, Cheol Keun Park, Eun Ju Son, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon, and Jung Hyun Yoon
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Thyroid gland ,Thyroid nodule ,Ultrasonography ,Biopsy, fine-needle ,Frozen sections ,Medical technology ,R855-855.5 - Abstract
Purpose: The goal of this study was to evaluate the clinicopathological and imaging features of thyroid nodules surgically diagnosed as hyaline trabecular tumor (HTT), and to assess the role of cytology and frozen sections (FS) in the diagnosis of HTT. Methods: This study included 21 thyroid nodules in 21 patients treated from August 2005 to March 2015 (mean age, 53.3 years) who were either diagnosed as HTT or had HTT suggested as a possible diagnosis based on cytology, FS, or the final pathology report. Patients’ medical records were retrospectively reviewed for cytopathologic results and outcomes during the course of follow-up. Sonograms were reviewed and categorized. Results: Twelve nodules from 12 patients were surgically confirmed as HTT. Ultrasonography (US)-guided fine needle aspiration (FNA) was performed on 11 nodules, of which six (54.5%) were papillary thyroid carcinoma (PTC) or suspicious for PTC and three (27.3%) were HTT or suspicious for HTT. Intraoperative FS suggested the possibility of HTT in seven nodules, of which four (57.1%) were confirmed as HTT. US-FNA suggested the diagnosis of HTT in 10 nodules, of which three (30.0%) were confirmed as HTT. Common US features of the 12 pathologically confirmed cases of HTT were hypoechogenicity or marked hypoechogenicity (83.4%), absence of calcifications (91.7%), parallel shape (100.0%), presence of vascularity (75.0%), and probable benignity (58.3%). Conclusion: HTT should be included in the differential diagnosis of solid tumors with hypoechogenicity or marked hypoechogenicity and otherwise benign US features that have been diagnosed as PTC through cytology.
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- 2016
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3. Associations between Bethesda categories and tumor characteristics of conventional papillary thyroid carcinoma
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Eun Kyung Kim, Jung Hyun Yoon, Vivian Youngjean Park, Jin Young Kwak, and Hee Jung Moon
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Oncology ,Thyroid nodules ,medicine.medical_specialty ,lcsh:Medical technology ,endocrine system diseases ,Node metastasis ,030209 endocrinology & metabolism ,Thyroid carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Biopsy, fine-needle ,Internal medicine ,Cytology ,medicine ,Radiology, Nuclear Medicine and imaging ,Pathological ,Thyroid nodule ,Ultrasonography ,Tumor size ,business.industry ,Thyroid cancer, papillary ,Odds ratio ,medicine.disease ,humanities ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Original Article ,business - Abstract
Purpose The aim of this study was to investigate the associations of Bethesda categories III, V, and VI with the clinical and pathological features of thyroid nodules surgically confirmed as conventional papillary thyroid carcinomas (PTCs). Methods We analyzed 1,990 consecutive patients diagnosed with conventional PTC at surgery with preoperative Bethesda categories III, V, or VI. We determined the odds ratio (ORs) of the clinical and pathological variables associated with categories III and V, using category VI as the reference. Results Category III and V PTCs had a smaller pathological tumor size (OR, 0.934 and OR, 0.969, respectively) and less frequently had central lymph node metastasis (OR, 0.487 and OR, 0.780, respectively) than category VI PTCs. Category III PTCs less frequently showed suspicious ultrasonographic features (OR, 0.296) than category VI PTCs, and category V PTCs less frequently had gross extrathyroidal extension, with borderline significance (OR, 0.643; P=0.059). Conclusion Conventional PTCs with a preoperative Bethesda category of III or V may less frequently exhibit poor prognostic factors than those with malignant cytology.
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- 2018
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4. Ultrasonography-guided 14-gauge core biopsy of the breast: results of 7 years of experience
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Hee Jung Moon, Jung Hyun Yoon, Min Jung Kim, Eun Kyung Kim, and Inha Jung
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medicine.medical_specialty ,lcsh:Medical technology ,Malignancy ,Image-guided biopsy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Breast ,Medical diagnosis ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Ductal carcinoma ,medicine.disease ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,business ,Core biopsy ,Image-Guided Biopsy - Abstract
Purpose This study assessed the outcomes of ultrasound (US)-guided core needle biopsies (CNBs) of breast lesions with at least 2 years of follow-up to determine the false-negative rate and to evaluate the diagnostic accuracy of CNB. Methods We retrospectively analyzed 13,254 consecutive US-guided 14-gauge CNBs for breast lesions. We excluded biopsies if non-malignant biopsy result was not confirmed by surgical excision or US-guided vacuum-assisted biopsy, or fewer than 2 years of follow-up data were available. A total of 4,186 biopsies were excluded, and 9,068 breast masses from 7,039 women were included. The pathologic findings from each CNB were assessed using the standard diagnostic reference, defined based on the results of surgical excision, vacuum-assisted biopsy, or at least 2 years of long-term imaging follow-up. The false-negative rate and underestimation rate were calculated. Results Of the 9,068 CNBs, benign pathology was found in 64.2%, high-risk results in 3.5%, and malignant results in 32.3%. Of the 5,821 benign CNBs, an additional malignancy was found at excision in 63 lesions, leading to a false-negative rate of 2.0% (63 of 3,067). The underestimation rate was 33.6% (111 of 330) for ductal carcinoma in situ and 24.5% (79 of 322) for high-risk results at surgical excision. Most false-negative diagnoses (84.1%, 53 of 63) were recognized through imaging-histology correlations, and immediate rebiopsies were performed. Ten malignancies (15.9%, 10 of 63) had delayed diagnoses and showed progression in follow-up US imaging. Conclusion US-guided 14-gauge CNB provided optimal diagnostic information. Imaging-histology correlations and appropriate imaging follow-up should be performed to avoid delayed diagnoses.
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- 2018
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5. Using ultrasonographic features to predict the outcomes of patients with small papillary thyroid carcinomas: a retrospective study implementing the 2015 ATA patterns and ACR TI-RADS categories.
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Hee Min Park, Jihye Lee, Jin Young Kwak, Youngjean Park, Vivian, Miribi Rho, Minah Lee, and Jung Hyun Yoon
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PAPILLARY carcinoma ,THYROID cancer ,BRAF genes ,LYMPHATIC metastasis ,CANCER relapse ,TREATMENT effectiveness - Abstract
Background: The aim of this study was to evaluate whether risk stratification systems using ultrasonographic (US) features show associations with the outcomes of patients with small papillary thyroid carcinomas (PTCs). Methods: This retrospective study received institutional review board approval. From March 2007 to February 2010, 775 patients who underwent surgery for small PTCs (10-20 mm) were included. Based on preoperative US features, PTCs were categorized according to the 2015 American Thyroid Association (ATA) guideline and the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS). The associations of clinicopathological and US features with postoperative patient outcomes were evaluated. Results: In total, 61 patients had high-volume central lymph node metastasis (CLNM, 7.9%) and 100 patients had lateral lymph node metastasis (LLNM, 12.9%). In univariable analyses, a high number of suspicious US features and higher ACR TI-RADS point totals were significantly associated with both high-volume CLNM (P=0.001, each) and LLNM (P<0.001, each). In multivariable analyses of preoperative features, a higher number of suspicious US features and higher ACR TI-RADS point totals were independently associated with high-volume CLNM (odds ratio [OR], 1.516 and 1.201; P=0.002 and P=0.001, respectively) and LLNM (OR, 1.763 and 1.293; all P<0.001). Individual US features, ATA categories, and ACR TI-RADS point totals were not significantly associated with recurrence or distant metastasis. Conclusion: The number of suspicious US features and the ACR TI-RADS point total are potential risk factors for cervical lymph node metastasis in patients with small PTCs. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Evaluating imaging-pathology concordance and discordance after ultrasound-guided breast biopsy
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Jung Hyun Yoon, Min Jung Kim, Vivian Youngjean Park, Hee Jung Moon, and Eun Kyung Kim
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Breast biopsy ,medicine.medical_specialty ,lcsh:Medical technology ,medicine.diagnostic_test ,business.industry ,Concordance ,Biopsy ,Ultrasound ,Diagnostic accuracy ,Review Article ,Ultrasound guided ,030218 nuclear medicine & medical imaging ,Review article ,03 medical and health sciences ,0302 clinical medicine ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Surgical biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Breast ,business ,Ultrasonography - Abstract
Ultrasound (US)-guided breast biopsy has become the main method for diagnosing breast pathology, and it has a high diagnostic accuracy, approaching that of open surgical biopsy. However, methods for confirming adequate lesion retrieval after US-guided biopsy are relatively limited and false-negative results are unavoidable. Determining imaging-pathology concordance after US-guided biopsy is essential for validating the biopsy result and providing appropriate management. In this review article, we briefly present the results of US-guided breast biopsy; describe general aspects to consider when establishing imaging-pathology concordance; and review the various categories of imaging-pathology correlations and corresponding management strategies.
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- 2017
7. Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy
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Ok Kyu Song, Hee Jung Moon, Jung Hyun Yoon, Eun Kyung Kim, Jin Young Kwak, and Ja Seung Koo
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Core needle ,medicine.medical_specialty ,Pathology ,lcsh:Medical technology ,Neoplasm metastasis ,030209 endocrinology & metabolism ,Lymph node metastasis ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Vascularity ,Clinical history ,Renal cell carcinoma ,Biopsy, fine-needle ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,neoplasms ,Carcinoma, renal cell ,Ultrasonography ,Thyroid gland ,medicine.diagnostic_test ,business.industry ,Biopsy, large-core needle ,Thyroid ,medicine.disease ,medicine.anatomical_structure ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,medicine.symptom ,business - Abstract
PURPOSE The aims of this study were to present the ultrasonographic (US) features of metastatic renal cell carcinoma (RCC) in the thyroid gland and to evaluate the diagnostic utility of fineneedle aspiration (FNA) and core needle biopsy (CNB). METHODS Eight patients with nine metastatic RCC nodules in the thyroid glands who were treated from January 2002 to March 2015 in a single tertiary hospital were consecutively selected and retrospectively reviewed. US features and clinical history were obtained from the institution's medical database. FNA was performed nine times on eight nodules and CNB was performed six times on six nodules. The diagnostic utility of FNA and CNB was evaluated. RESULTS All nine nodules showed mass formation without diffuse thyroid involvement. On ultrasonography, metastatic RCC nodules were solid (100%), hypoechoic (100%), and ovalshaped nodules with a well-defined smooth margin (88.9%) and increased vascularity (100%, with 55% showing extensive vascularity). No calcifications were noted in any nodules. Lymph node metastasis and direct extension to nearby structures beyond the thyroid gland were not found. One FNA (11%) was able to confirm metastatic RCC, whereas all six CNBs confirmed metastatic RCC. CONCLUSION Metastatic RCC appears as oval-shaped hypoechoic solid nodules with well-defined smooth margins, no calcifications, and increased vascularity on ultrasonography. Characteristic US features along with a previous history of RCC should raise clinical suspicion, and CNB should be performed to make an accurate diagnosis.
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- 2017
8. Ultrasonographic evaluation of women with pathologic nipple discharge
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Jung Hyun Yoon, Hee Jung Moon, Haesung Yoon, Youngjean Vivian Park, Min Jung Kim, and Eun Kyung Kim
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medicine.medical_specialty ,lcsh:Medical technology ,Breast imaging ,Review Article ,030218 nuclear medicine & medical imaging ,Nipple discharge ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Breast diseases ,Medicine ,Mammography ,Radiology, Nuclear Medicine and imaging ,In patient ,Breast ,skin and connective tissue diseases ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Breast ultrasonography ,Magnetic resonance imaging ,medicine.disease ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Radiology ,Differential diagnosis ,medicine.symptom ,business - Abstract
Nipple discharge is a common symptom that is alarming for the patient since it can be a presenting symptom of breast cancer. Breast imaging is used to examine women with pathologic nipple discharge in order to detect any lesions that may be present and to assist in the differential diagnosis. The modalities of breast imaging include mammography, breast ultrasonography (US), and magnetic resonance imaging. Breast US is currently considered to be useful for the visualization of ductal structures and intraductal lesions that cause nipple discharge. In this review, we discuss US techniques that assist in the clear visualization of ductal structures and intraductal lesions in patients with nipple discharge. Controversy remains regarding the evaluation and management of patients with nipple discharge, and we summarize the results available in the currently published literature.
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- 2017
9. Magnetic resonance imaging and pathological characteristics of pure mucinous carcinoma in the breast according to echogenicity on ultrasonography
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Eun Kyung Kim, Hee Jung Moon, Min Jung Kim, Jung Hyun Yoon, and Young Gyung Shin
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medicine.medical_specialty ,lcsh:Medical technology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Magnetic resonance imaging ,medicine ,Adenocarcinoma, mucinous ,Mucinous carcinoma ,Radiology, Nuclear Medicine and imaging ,Mucinous Breast Carcinoma ,Pathological ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Echogenicity ,medicine.disease ,Signal on ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Original Article ,Radiology ,Breast neoplasms ,business - Abstract
Purpose The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). Methods Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups. Results Eleven cases of PMBC (33.3%) exhibited hypoechogenicity on US, while 22 cases (66.7%) exhibited isoechogenicity or hyperechogenicity. Of the isoechogenic to hyperechogenic PMBCs, 95.5% showed a high signal on T2-weighted images, which was a significantly greater percentage than was observed for the hypoechogenic group (54.5%) (P=0.010). Of the hypoechogenic PMBCs, 63.6% showed a washout pattern in the delayed phase, which was substantially more than the result of 23.8% observed for the isoechogenic to hyperechogenic PMBCs (P=0.053). Conclusion PMBCs with isoechogenicity or hyperechogenicity were more likely to show a high signal intensity on T2-weighted images than hypoechogenic PMBCs. However, other MR imaging and clinicohistopathological characteristics were not significantly different between the two groups.
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- 2017
10. Clinical application of S-Detect to breast masses on ultrasonography: a study evaluating the diagnostic performance and agreement with a dedicated breast radiologist
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Kiwook Kim, Jung Hyun Yoon, Eun Kyung Kim, and Mi Kyung Song
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medicine.medical_specialty ,lcsh:Medical technology ,Breast imaging ,BI-RADS ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Cohen's kappa ,Neoplasms ,Medicine ,Cutoff ,Radiology, Nuclear Medicine and imaging ,Breast ,Ultrasonography ,Receiver operating characteristic ,business.industry ,Breast ultrasonography ,Diagnosis, computer-aided ,Predictive value ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,business - Abstract
PURPOSE The purpose of this study was to evaluate the diagnostic performance of S-Detect when applied to breast ultrasonography (US), and the agreement with an experienced radiologist specializing in breast imaging. METHODS From June to August 2015, 192 breast masses in 175 women were included. US features of the breast masses were retrospectively analyzed by a radiologist who specializes in breast imaging and S-Detect, according to the fourth edition of the American College of Radiology Breast Imaging Reporting and Data System lexicon and final assessment categories. Final assessments from S-Detect were in dichotomized form: possibly benign and possibly malignant. Kappa statistics were used to analyze the agreement between the radiologist and S-Detect. Diagnostic performance of the radiologist and S-Detect was calculated, including sensitivity, specificity, positive predictive value (PPV), negative predictive value, accuracy, and area under the receiving operator characteristics curve. RESULTS Of the 192 breast masses, 72 (37.5%) were malignant, and 120 (62.5%) were benign. Benign masses among category 4a had higher rates of possibly benign assessment on S-Detect for the radiologist, 63.5% to 36.5%, respectively (P=0.797). When the cutoff was set at category 4a, the specificity, PPV, and accuracy was significantly higher in S-Detect compared to the radiologist (all P
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- 2017
11. Validation of the fifth edition BI-RADS ultrasound lexicon with comparison of fourth and fifth edition diagnostic performance using video clips
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You Me Kim, Ji Hyun Youk, Sun Hye Jeong, Sung Hun Kim, Min Jung Kim, Hye Sun Lee, and Jung Hyun Yoon
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medicine.medical_specialty ,lcsh:Medical technology ,Breast imaging ,Biopsy ,BI-RADS ,Lexicon ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast Imaging Reporting and Data System (BI-RADS) ,Medicine ,Radiology, Nuclear Medicine and imaging ,CLIPS ,Ultrasonography ,computer.programming_language ,Receiver operating characteristic ,business.industry ,Ultrasound ,Video image ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,Breast neoplasms ,business ,computer - Abstract
Purpose The aim of this study was to evaluate the positive predictive value (PPV) and the diagnostic performance of the ultrasonographic descriptors in the fifth edition of BI-RADS, comparing with the fourth edition using video clips. Methods From September 2013 to July 2014, 80 breast masses in 74 women (mean age, 47.5±10.7 years) from five institutions of the Korean Society of Breast Imaging were included. Two radiologists individually reviewed the static and video images and analyzed the images according to the fourth and fifth edition of BI-RADS. The PPV of each descriptor was calculated and diagnostic performances between the fourth and fifth editions were compared. Results Of the 80 breast masses, 51 (63.8%) were benign and 29 (36.2%) were malignant. Suspicious ultrasonographic features such as irregular shape, non-parallel orientation, angular or spiculated margins, and combined posterior features showed higher PPV in both editions (all P0.05). The area under the receiver operating characteristics curve was higher in the fourth edition (0.708 to 0.690), without significance (P=0.416). Conclusion The fifth edition of the BI-RADS ultrasound lexicon showed comparable performance to the fourth edition and can be useful in the differential diagnosis of breast masses using ultrasonography.
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- 2016
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12. Hyalinizing trabecular tumor of the thyroid: diagnosis of a rare tumor using ultrasonography, cytology, and intraoperative frozen sections
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Cheol Keun Park, Hyunsik Jang, Eun Kyung Kim, Eun Ju Son, Jin Young Kwak, Jung Hyun Yoon, and Hee Jung Moon
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Thyroid nodules ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pathology ,lcsh:Medical technology ,animal diseases ,030209 endocrinology & metabolism ,Thyroid carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Biopsy, fine-needle ,Cytology ,mental disorders ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Hyaline ,Thyroid nodule ,Ultrasonography ,Thyroid gland ,medicine.diagnostic_test ,business.industry ,Frozen sections ,Thyroid ,medicine.disease ,nervous system diseases ,Fine-needle aspiration ,medicine.anatomical_structure ,lcsh:R855-855.5 ,nervous system ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,Differential diagnosis ,business - Abstract
Purpose The goal of this study was to evaluate the clinicopathological and imaging features of thyroid nodules surgically diagnosed as hyaline trabecular tumor (HTT), and to assess the role of cytology and frozen sections (FS) in the diagnosis of HTT. Methods This study included 21 thyroid nodules in 21 patients treated from August 2005 to March 2015 (mean age, 53.3 years) who were either diagnosed as HTT or had HTT suggested as a possible diagnosis based on cytology, FS, or the final pathology report. Patients' medical records were retrospectively reviewed for cytopathologic results and outcomes during the course of follow-up. Sonograms were reviewed and categorized. Results Twelve nodules from 12 patients were surgically confirmed as HTT. Ultrasonography (US)-guided fine needle aspiration (FNA) was performed on 11 nodules, of which six (54.5%) were papillary thyroid carcinoma (PTC) or suspicious for PTC and three (27.3%) were HTT or suspicious for HTT. Intraoperative FS suggested the possibility of HTT in seven nodules, of which four (57.1%) were confirmed as HTT. US-FNA suggested the diagnosis of HTT in 10 nodules, of which three (30.0%) were confirmed as HTT. Common US features of the 12 pathologically confirmed cases of HTT were hypoechogenicity or marked hypoechogenicity (83.4%), absence of calcifications (91.7%), parallel shape (100.0%), presence of vascularity (75.0%), and probable benignity (58.3%). Conclusion HTT should be included in the differential diagnosis of solid tumors with hypoechogenicity or marked hypoechogenicity and otherwise benign US features that have been diagnosed as PTC through cytology.
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- 2016
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13. A superficial hyperechoic band in human articular cartilage on ultrasonography with histological correlation: preliminary observations
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Tae Sun Han, Byoung-Hyun Min, Sunghoon Park, Seung-Hyun Yoon, Kyi Beom Lee, Kyu-Sung Kwack, and Hyun Young Lee
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Pathology ,medicine.medical_specialty ,Histology ,lcsh:Medical technology ,business.industry ,Cartilage ,Articular cartilage ,Stain ,Knee joint ,Staining ,medicine.anatomical_structure ,lcsh:R855-855.5 ,medicine ,Radiology, Nuclear Medicine and imaging ,Trichrome stain ,Original Article ,Ultrasonography ,business ,Kappa - Abstract
PURPOSE: To demonstrate the superficial hyperechoic band (SHEB) in articular cartilage by using ultrasonography (US) and to assess its correlation with histological images. METHODS: In total, 47 regions of interest (ROIs) were analyzed from six tibial osteochondral specimens (OCSs) that were obtained after total knee arthroplasty. Ultrasonograms were obtained for each OCS. Then, matching histological sections from all specimens were obtained for comparison with the ultrasonograms. Two types of histological staining were used: Safranin-O stain (SO) to identify glycosaminoglycans (GAG) and Masson's trichrome stain (MT) to identify collagen. In step 1, two observers evaluated whether there was an SHEB in each ROI. In step 2, the two observers evaluated which histological staining method correlated better with the SHEB by using the ImageJ software. RESULTS: In step 1 of the analysis, 20 out of 47 ROIs showed an SHEB (42.6%, kappa=0.579). Step 2 showed that the SHEB correlated significantly better with the topographical variation in stainability in SO staining, indicating the GAG distribution, than with MT staining, indicating the collagen distribution (P
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- 2015
14. Vacuum-assisted breast biopsy under sonographic guidance: analysis of 10 years of experience
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Jung Hyun Yoon, Seung-Hyun Lee, Hee Jung Moon, Min Jung Kim, and Eun Kyung Kim
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Breast biopsy ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Diagnostic accuracy ,Gold standard (test) ,Ductal carcinoma ,Malignancy ,medicine.disease ,Vacuum-assisted breast biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Image-Guided Biopsy ,business ,Pathological - Abstract
Purpose To determine the indications and the diagnostic accuracy of vacuum-assisted breast biopsy (VABB) under ultrasonographic (US) guidance based on a 10-year period of clinical use. Methods This was a retrospective analysis of 2,920 breast lesions in 2,477 consecutive patients who underwent US-guided VABB between February 2002 and December 2011. The proportions of each indication for VABB were analyzed as well as the trend of its use over divided time periods. Histopathological diagnosis and the malignancy rate of the lesions with VABB were analyzed. A comparison of the pathological diagnosis of VABB and the gold standard diagnosis revealed the false negative rate, the underestimation rate, and the agreement rate. Results Palpable lesions (44.4%), low-suspicion lesions (15.7%), high-risk lesions (12.4%), and calcifications (10.3%) were the most common indications for US-guided VABB. The malignancy rate of lesions submitted to VABB was 5.4%. The false negative rate was only 0.1%, while the underestimation rate of high-risk lesions and ductal carcinoma in situ was 3.1% and 13.8%, respectively, with a 98.7% agreement rate. Among 1,512 therapeutic VABB cases, 84.9% showed no residual or recurrent lesions on long term follow-up US for more than a year. Complications occurred in 1% of the patients without need for surgical intervention. Conclusion US-guided VABB is an accurate and safe method that can help decision-making in the diagnostic process and can be an alternative for excisional surgery in some therapeutic circumstances.
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- 2014
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15. Comparison of breast tissue markers for tumor localization in breast cancer patients undergoing neoadjuvant chemotherapy.
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Ja Ho Koo, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, and Min Jung Kim
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TUMOR markers ,BREAST ,BREAST cancer ,FISHER exact test ,BREAST ultrasound ,CANCER patients - Abstract
Purpose: The purpose of this study was to compare the visibility of breast tissue markers in cases of breast cancer on ultrasonography (US) after neoadjuvant chemotherapy (NAC) and to analyze whether the type of marker affected the choice of localization method after NAC. Methods: We included 153 tissue markers inserted within breast cancers that showed pathologically complete response (pCR) after NAC from January 2012 to April 2017. One of three types of markers (a surgical clip, Cormark, or UltraClip) was inserted. Medical records and imaging findings were retrospectively reviewed. We compared the visibility of the different types of tissue markers on US after NAC, and also compared the imaging modalities used in the preoperative localization. The chi-square test, Fisher exact test, and multiple logistic regression were used for analysis. Results: Of the 153 tissue markers, 56 were surgical clips, 61 Cormark, and 36 UltraClip. After NAC, residual lesions were not seen on US in 42 cases (27.5%). In multivariate analysis, the visibility of the surgical clips and Cormark markers was better than that of the UltraClip markers (odds ratio [OR], 5.467; 95% confidence interal [CI], 1.717 to 17.410; P=0.004 and OR, 3.045; 95% CI, 1.074 to 8.628; P=0.036, respectively). Among the 131 cases where localization targeting the marker was required, the proportion of US-guided localizations was significantly higher when a surgical clip was used than when an UltraClip marker was used (OR, 5.566; 95% CI, 1.610 to 19.246; P=0.007) in the multivariate analysis. Conclusion: The type of breast tissue marker affected its visibility on US in cases with pCR after NAC, which in turn affected the localization methodology. [ABSTRACT FROM AUTHOR]
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- 2019
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16. Associations between Bethesda categories and tumor characteristics of conventional papillary thyroid carcinoma.
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Park, Vivian Youngjean, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, and Hee Jung Moon
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THYROID cancer treatment ,PAPILLARY carcinoma ,CLINICAL trials ,THERAPEUTICS - Abstract
Purpose: The aim of this study was to investigate the associations of Bethesda categories III, V, and VI with the clinical and pathological features of thyroid nodules surgically confirmed as conventional papillary thyroid carcinomas (PTCs). Methods: We analyzed 1,990 consecutive patients diagnosed with conventional PTC at surgery with preoperative Bethesda categories III, V, or VI. We determined the odds ratio (ORs) of the clinical and pathological variables associated with categories III and V, using category VI as the reference. Results: Category III and V PTCs had a smaller pathological tumor size (OR, 0.934 and OR, 0.969, respectively) and less frequently had central lymph node metastasis (OR, 0.487 and OR, 0.780, respectively) than category VI PTCs. Category III PTCs less frequently showed suspicious ultrasonographic features (OR, 0.296) than category VI PTCs, and category V PTCs less frequently had gross extrathyroidal extension, with borderline significance (OR, 0.643; P=0.059). Conclusion: Conventional PTCs with a preoperative Bethesda category of III or V may less frequently exhibit poor prognostic factors than those with malignant cytology. [ABSTRACT FROM AUTHOR]
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- 2018
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17. Evaluating imaging-pathology concordance and discordance after ultrasound-guided breast biopsy.
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Vivian Youngjean Park, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, and Min Jung Kim
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BREAST biopsy ,ULTRASONIC imaging - Abstract
Ultrasound (US)-guided breast biopsy has become the main method for diagnosing breast pathology, and it has a high diagnostic accuracy, approaching that of open surgical biopsy. However, methods for confirming adequate lesion retrieval after US-guided biopsy are relatively limited and false-negative results are unavoidable. Determining imaging-pathology concordance after US-guided biopsy is essential for validating the biopsy result and providing appropriate management. In this review article, we briefly present the results of US-guided breast biopsy; describe general aspects to consider when establishing imaging-pathology concordance; and review the various categories of imaging-pathology correlations and corresponding management strategies. [ABSTRACT FROM AUTHOR]
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- 2018
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18. Which supplementary imaging modality should be used for breast ultrasonography? Comparison of the diagnostic performance of elastography and computer-aided diagnosis.
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Si Eun Lee, Ji Eun Moon, Yun Ho Rho, Eun-Kyung Kim, and Jung Hyun Yoon
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BREAST ultrasound ,DIAGNOSTIC imaging ,ELASTOGRAPHY - Abstract
Purpose: The aim of this study was to evaluate and compare the diagnostic performance of grayscale ultrasonography (US), US elastography, and US computer-aided diagnosis (US-CAD) in the differential diagnosis of breast masses. Methods: A total of 193 breast masses in 175 consecutive women (mean age, 46.4 years) from June to August 2015 were included. US and elastography images were obtained and recorded. A US-CAD system was applied to the grayscale sonograms, which were automatically analyzed and visualized in order to generate a final assessment. The final assessments of breast masses were based on the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) categories, while elasticity scores were assigned using a 5-point scoring system. The diagnostic performance of grayscale US, elastography, and US-CAD was calculated and compared. Results: Of the 193 breast masses, 120 (62.2%) were benign and 73 (37.8%) were malignant. Breast masses had significantly higher rates of malignancy in BI-RADS categories 4c and 5, elastography patterns 4 and 5, and when the US-CAD assessment was possibly malignant (all P<0.001). Elastography had higher specificity (40.8%, P=0.042) than grayscale US. US-CAD showed the highest specificity (67.5%), positive predictive value (PPV) (61.4%), accuracy (74.1%), and area under the curve (AUC) (0.762, all P<0.05) among the three diagnostic tools. Conclusion: US-CAD had higher values for specificity, PPV, accuracy, and AUC than grayscale US or elastography. Computer-based analysis based on the morphologic features of US may be very useful in improving the diagnostic performance of breast US. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Magnetic resonance imaging and pathological characteristics of pure mucinous carcinoma in the breast according to echogenicity on ultrasonography.
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Young Gyung Shin, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, and Hee Jung Moon
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MAGNETIC resonance imaging ,BREAST cancer ,MUCINOUS adenocarcinoma - Abstract
Purpose: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). Methods: Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups. Results: Eleven cases of PMBC (33.3%) exhibited hypoechogenicity on US, while 22 cases (66.7%) exhibited isoechogenicity or hyperechogenicity. Of the isoechogenic to hyperechogenic PMBCs, 95.5% showed a high signal on T2-weighted images, which was a significantly greater percentage than was observed for the hypoechogenic group (54.5%) (P=0.010). Of the hypoechogenic PMBCs, 63.6% showed a washout pattern in the delayed phase, which was substantially more than the result of 23.8% observed for the isoechogenic to hyperechogenic PMBCs (P=0.053). Conclusion: PMBCs with isoechogenicity or hyperechogenicity were more likely to show a high signal intensity on T2-weighted images than hypoechogenic PMBCs. However, other MR imaging and clinicohistopathological characteristics were not significantly different between the two groups. [ABSTRACT FROM AUTHOR]
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- 2017
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20. Validation of the fifth edition BI-RADS ultrasound lexicon with comparison of fourth and fifth edition diagnostic performance using video clips.
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Jung Hyun Yoon, Min Jung Kim, Hye Sun Lee, Sung Hun Kim, Ji Hyun Youk, Sun Hye Jeong, and You Me Kim
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- *
BREAST cancer , *BIOPSY , *ULTRASONIC imaging - Abstract
Purpose: The aim of this study was to evaluate the positive predictive value (PPV) and the diagnostic performance of the ultrasonographic descriptors in the fifth edition of BI-RADS, comparing with the fourth edition using video clips. Methods: From September 2013 to July 2014, 80 breast masses in 74 women (mean age, 47.5±10.7 years) from five institutions of the Korean Society of Breast Imaging were included. Two radiologists individually reviewed the static and video images and analyzed the images according to the fourth and fifth edition of BI-RADS. The PPV of each descriptor was calculated and diagnostic performances between the fourth and fifth editions were compared. Results: Of the 80 breast masses, 51 (63.8%) were benign and 29 (36.2%) were malignant. Suspicious ultrasonographic features such as irregular shape, non-parallel orientation, angular or spiculated margins, and combined posterior features showed higher PPV in both editions (all P<0.05). No significant differences were found in the diagnostic performances between the two editions (all P>0.05). The area under the receiver operating characteristics curve was higher in the fourth edition (0.708 to 0.690), without significance (P=0.416). Conclusion: The fifth edition of the BI-RADS ultrasound lexicon showed comparable performance to the fourth edition and can be useful in the differential diagnosis of breast masses using ultrasonography. [ABSTRACT FROM AUTHOR]
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- 2016
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21. Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis.
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Jonghyeon Kim, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, and Jung Hyun Yoon
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FIBROCYSTIC breast disease ,DIAGNOSTIC ultrasonic imaging ,BREAST biopsy ,DIAGNOSIS - Abstract
Purpose: The goal of this study was to evaluate the imaging features of diabetic mastopathy (DMP) and the role of image-guided biopsy in its diagnosis. Methods: Two experienced radiologists retrospectively reviewed the mammographic and sonographic images of 19 pathologically confirmed DMP patients. The techniques and results of the biopsies performed in each patient were also reviewed. Results: Mammograms showed negative findings in 78% of the patients. On ultrasonography (US), 13 lesions were seen as masses and six as non-mass lesions. The US features of the mass lesions were as follows: irregular shape (69%), oval shape (31%), indistinct margin (69%), angular margin (15%), microlobulated margin (8%), well-defined margin (8%), heterogeneous echogenicity (62%), hypoechoic echogenicity (38%), posterior shadowing (92%), parallel orientation (100%), the absence of calcifications (100%), and the absence of vascularity (100%). Based on the US findings, 17 lesions (89%) were classified as Breast Imaging Reporting and Data System category 4 and two (11%) as category 3. US-guided core biopsy was performed in 18 patients, and 10 (56%) were diagnosed with DMP on that basis. An additional vacuumassisted biopsy was performed in seven patients and all were diagnosed with DMP. Conclusion: The US features of DMP were generally suspicious for malignancy, whereas the mammographic findings were often negative or showed only focal asymmetry. Core biopsy is an adequate method for initial pathological diagnosis. However, since it yields non-diagnostic results in a considerable number of cases, the evaluation of correlations between imaging and pathology plays an important role in the diagnostic process. [ABSTRACT FROM AUTHOR]
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- 2016
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22. The follicular variant of papillary thyroid carcinoma: characteristics of preoperative ultrasonography and cytology.
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Jung Hyun Yoon, Hyeong Ju Kwon, Eun-Kyung Kim, Hee Jung Moon, and Jin Young Kwak
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- *
ULTRASONIC imaging , *THYROID cancer , *CYTOLOGY - Abstract
Purpose: The goal of this study was to validate the ultrasonography (US) and cytopathological features that are used in the diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) and to characterize the role of BRAFV600E mutation analysis in the diagnosis of FVPTC. Methods: From May 2012 to February 2014, 40 thyroid nodules from 40 patients (mean age, 56.2 years; range, 26 to 81 years) diagnosed with FVPTC were included in this study. The US features of the nodules were analyzed and the nodules were classified as probably benign or suspicious for malignancy. Twenty-three thyroid nodules (57.5%) underwent BRAFV600E mutation analysis. Clinical information and histopathologic results were obtained by reviewing the medical records of the patients. Results: Thirty nodules (75.0%) were classified as suspicious for malignancy, while 10 (25.0%) were classified as probably benign. Seven of the eight nodules (87.5%) with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytology showed suspicious US features, while one of the two nodules (50.0%) with follicular neoplasm cytology presented suspicious US features. Five of the 23 nodules (21.7%) that underwent BRAFV600E mutation analysis had positive results, all of which were diagnosed as suspicious for malignancy or malignant based on cytology. None of the nodules with benign, AUS/FLUS, or follicular neoplasm cytology were positive for the BRAFV600E mutation. Conclusion: US features allow nodules to be classified as suspicious for malignancy, and the presence of suspicious US features in nodules with ambiguous cytology may aid in the diagnosis of FVPTC. BRAFV600E mutation analysis is of limited value in the diagnosis of FVPTC. [ABSTRACT FROM AUTHOR]
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- 2016
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23. Transperineal ultrasonography for evaluation of the perianal fistula and abscess in pediatric Crohn disease: preliminary study.
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Jae-Yeon Hwang, Hye-Kyung Yoon, Wee Kyoung Kim, Young Ah Cho, Jin Seong Lee, Chong Hyun Yoon, Yeoun Joo Lee, and Kyung Mo Kim
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DIAGNOSTIC ultrasonic imaging ,FISTULA ,ABSCESSES ,CROHN'S disease ,COLOR Doppler ultrasonography ,DIAGNOSIS - Abstract
Purpose: To assess the feasibility and effectiveness of transperineal ultrasonography (TPUS) for the evaluation of perianal Crohn disease (PCD) in pediatric patients. Methods: Between September 2010 and August 2013, 64 TPUS examinations were performed in 43 patients (34 males and 9 females; mean age±standard deviation, 13.3±2.4 years; age range, 6 to 17 years) to evaluate PCD. The pain severity, location, and activity of perianal fistula, the presence of an abscess, and anal canal hyperemia were retrospectively evaluated. Spearman rank correlation analysis was performed to assess the relationship between the severity of the pain and the fistula activity, the presence of an abscess, and anal canal hyperemia. Results: All examinations were successfully performed. Thirty-nine examinations (60.9%) were performed without any pain experienced by the patient, 19 examinations (29.7%) with mild pain, five examinations (7.8%) with moderate pain, and one examination (1.6%) with severe pain. The pain severity was correlated with the fistula activity (P<0.01). An anterior fistula location was more common than a posterior location. Active fistulas and abscesses were identified during 30 examinations (46.9%) and 12 examinations (18.8%), respectively. Anal canal hyperemia was identified in 31 examinations (48.4%). Conclusion: TPUS with a color Doppler study is useful for visualizing a perianal fistula or abscess and for assessing its inflammatory activity in pediatric Crohn patients. [ABSTRACT FROM AUTHOR]
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- 2014
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24. Associations between Bethesda categories and tumor characteristics of conventional papillary thyroid carcinoma
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Vivian Youngjean Park, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, and Hee Jung Moon
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Thyroid nodule ,Biopsy, fine-needle ,Thyroid cancer, papillary ,Ultrasonography ,Medical technology ,R855-855.5 - Abstract
Purpose The aim of this study was to investigate the associations of Bethesda categories III, V, and VI with the clinical and pathological features of thyroid nodules surgically confirmed as conventional papillary thyroid carcinomas (PTCs). Methods We analyzed 1,990 consecutive patients diagnosed with conventional PTC at surgery with preoperative Bethesda categories III, V, or VI. We determined the odds ratio (ORs) of the clinical and pathological variables associated with categories III and V, using category VI as the reference. Results Category III and V PTCs had a smaller pathological tumor size (OR, 0.934 and OR, 0.969, respectively) and less frequently had central lymph node metastasis (OR, 0.487 and OR, 0.780, respectively) than category VI PTCs. Category III PTCs less frequently showed suspicious ultrasonographic features (OR, 0.296) than category VI PTCs, and category V PTCs less frequently had gross extrathyroidal extension, with borderline significance (OR, 0.643; P=0.059). Conclusion Conventional PTCs with a preoperative Bethesda category of III or V may less frequently exhibit poor prognostic factors than those with malignant cytology.
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- 2018
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25. Ultrasonography-guided 14-gauge core biopsy of the breast: results of 7 years of experience
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Inha Jung, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon, and Eun-Kyung Kim
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Breast ,Ultrasonography ,Image-guided biopsy ,Medical technology ,R855-855.5 - Abstract
Purpose This study assessed the outcomes of ultrasound (US)-guided core needle biopsies (CNBs) of breast lesions with at least 2 years of follow-up to determine the false-negative rate and to evaluate the diagnostic accuracy of CNB. Methods We retrospectively analyzed 13,254 consecutive US-guided 14-gauge CNBs for breast lesions. We excluded biopsies if non-malignant biopsy result was not confirmed by surgical excision or US-guided vacuum-assisted biopsy, or fewer than 2 years of follow-up data were available. A total of 4,186 biopsies were excluded, and 9,068 breast masses from 7,039 women were included. The pathologic findings from each CNB were assessed using the standard diagnostic reference, defined based on the results of surgical excision, vacuum-assisted biopsy, or at least 2 years of long-term imaging follow-up. The false-negative rate and underestimation rate were calculated. Results Of the 9,068 CNBs, benign pathology was found in 64.2%, high-risk results in 3.5%, and malignant results in 32.3%. Of the 5,821 benign CNBs, an additional malignancy was found at excision in 63 lesions, leading to a false-negative rate of 2.0% (63 of 3,067). The underestimation rate was 33.6% (111 of 330) for ductal carcinoma in situ and 24.5% (79 of 322) for high-risk results at surgical excision. Most false-negative diagnoses (84.1%, 53 of 63) were recognized through imaging-histology correlations, and immediate rebiopsies were performed. Ten malignancies (15.9%, 10 of 63) had delayed diagnoses and showed progression in follow-up US imaging. Conclusion US-guided 14-gauge CNB provided optimal diagnostic information. Imaging-histology correlations and appropriate imaging follow-up should be performed to avoid delayed diagnoses.
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- 2018
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26. Vacuum-assisted breast biopsy under ultrasonographic guidance: analysis of a 10-year experience
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Seung Hyun Lee, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, and Jung Hyun Yoon
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Breast ,Image-guided biopsy ,Breast neoplasms ,Ultrasonography ,Medical technology ,R855-855.5 - Abstract
Purpose: To determine the indications and the diagnostic accuracy of vacuum-assisted breast biopsy (VABB) under ultrasonographic (US) guidance based on a 10-year period of clinical use. Methods: This was a retrospective analysis of 2,920 breast lesions in 2,477 consecutive patients who underwent US-guided VABB between February 2002 and December 2011. The proportions of each indication for VABB were analyzed as well as the trend of its use over divided time periods. Histopathological diagnosis and the malignancy rate of the lesions with VABB were analyzed. A comparison of the pathological diagnosis of VABB and the gold standard diagnosis revealed the false negative rate, the underestimation rate, and the agreement rate. Results: Palpable lesions (44.4%), low-suspicion lesions (15.7%), high-risk lesions (12.4%), and calcifications (10.3%) were the most common indications for US-guided VABB. The malignancy rate of lesions submitted to VABB was 5.4%. The false negative rate was only 0.1%, while the underestimation rate of high-risk lesions and ductal carcinoma in situ was 3.1% and 13.8%, respectively, with a 98.7% agreement rate. Among 1,512 therapeutic VABB cases, 84.9% showed no residual or recurrent lesions on long term follow-up US for more than a year. Complications occurred in 1% of the patients without need for surgical intervention. Conclusion: US-guided VABB is an accurate and safe method that can help decision-making in the diagnostic process and can be an alternative for excisional surgery in some therapeutic circumstances.
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- 2014
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27. Sonographic features and ultrasonography-guided fine-needle aspiration of metastases to the thyroid gland
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Jung Hyun Yoon, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon, and Ga Ram Kim
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Thyroid glandkwd Ultrasonographykwd Neoplasm metastasiskwd Biopsy, fine needle ,Medical technology ,R855-855.5 - Abstract
Purpose: To evaluate the characteristic ultrasonographic (US) features of metastatic carcinoma to the thyroid, and how accurate US features and ultrasonography-guided fine-needle aspiration (US-FNA) are for the diagnosis of thyroid metastases. Methods: Twenty-three thyroid lesions in 23 patients (mean age, 66.7 years; range, 46 to 85 years) that had been diagnosed as thyroid metastases were included. The composition, echogenicity, margin, shape, presence of calcifications, underlying parenchymal echotexture, and vascularity were analyzed in US images of the thyroid metastases. Final US assessments were categorized into probably benign and suspicious malignancy. The presence of suspicious metastatic cervical lymph nodes was noted. The medical records, US-FNA cytology, and pathology reports of these patients were retrospectively reviewed. Results: Of the 23 thyroid lesions, the general US appearance was mass-forming in 21 (91.3%) and non-mass-forming in 2 (8.7%). All 23 lesions showed a solid tumor composition. Common US features among the 21 mass-forming thyroid metastases were hypoechogenicity (81.0%), non-circumscribed margins (90.5%), no calcifications (76.2%), and parallel shape (81.0%). Suspicious cervical lymph nodes were present in 18 patients (78.3%). Of the 23 lesions, 21 (91.3%) were classified as suspicious malignancy, and 2 (8.7%) as probably benign. US-FNA showed diagnostic results specific for metastases in 21 of the 22 patients (95.5%) who had undergone US-FNA. Conclusion: Common US features in thyroid metastasis were hypoechogenicity, non-circumscribed margins, no calcifications, parallel shape, and the presence of suspicious cervical lymph nodes. US-FNA can be effectively used in the diagnosis of thyroid metastasis, preventing unnecessary surgery.
- Published
- 2014
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