1. [Activity of glutathione-S-transferase in the blood plasma, liver and crystalline lens tissues as affected by low doses of ionizing radiation and polychromatic light].
- Author
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Leus NF, Kolomiĭchuk SG, and Lishchenko VB
- Subjects
- Animals, Dose-Response Relationship, Radiation, Glutathione Transferase blood, Glutathione Transferase metabolism, Lens, Crystalline enzymology, Liver enzymology, Male, Rabbits, Glutathione Transferase radiation effects, Lens, Crystalline radiation effects, Light, Liver radiation effects
- Abstract
The developmental dynamics of pathologic changes in the lenses and activity of glutathione-S-transferase in the blood plasma, liver and lens tissues of rabbits under chronic influence (2 months) of small doses of X-ray radiation (total dose 2 Gy) and polychromatic light have been researched. It was shown, that polychromatic light and X-ray irradiation of rabbits significantly affected the lens nativity and increased the developmental frequency and the intensity of lens opacities. It was determined, that activity of glutathione-S-transferase in blood plasma increased for 1 month after the beginning of X-ray effects. The same effect on the enzymatic activity was shown by the summary influence of polychromatic light and X-ray irradiation. Glutathione-S-transferase activity decreased during 2 months as compared with the initial values, before irradiation of the animals. The enzymatic activity was increased in rabbit-liver cytoplasm by X-ray irradiation in 2 months. A decrease of glutathione-S-transferase activity in the liver, cortex and lens nucleus was determined under the influence of both X-ray radiation and polychromatic light.
- Published
- 1997