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5 results on '"Hansen JW"'

1. [The cause of cytopenia of undetermined significance can often be found by using next generation sequencing].

Author

Hansen JW, Husby S, and Grønbæk K

Subjects
Clone Cells, DNA Mutational Analysis, Hematopoiesis genetics, Humans, Leukemia, Myeloid, Acute blood, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Mutation, Myelodysplastic Syndromes blood, Myelodysplastic Syndromes diagnosis, Myelodysplastic Syndromes genetics, Risk Factors, Pancytopenia blood, Pancytopenia diagnosis, Pancytopenia genetics
Abstract

Patients with persistent cytopenia are frequently referred to the haematological departments , and a diagnosis of myelodysplastic syndrome is often suspected. After routine assessment including a broad range of blood tests, bone marrow biopsy, and cytogenetics, a definite diagnosis can still not be found for some patients, although they have symptomatic cytopenia. In these cases, next generation sequencing is a valuable supplement in identifying patients with early stages of myeloid cancer.

Published
2017

2. [Paraneoplastic pancytopenia in a patient with undiagnosed lung cancer].

Author

Hansen JW, Sjö L, and Grønbæk K

Subjects
Aged, Fatal Outcome, Female, Humans, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute pathology, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Pancytopenia pathology, Paraneoplastic Syndromes pathology, Small Cell Lung Carcinoma diagnosis, Small Cell Lung Carcinoma pathology, Leukemia, Myeloid, Acute complications, Lung Neoplasms complications, Pancytopenia etiology, Paraneoplastic Syndromes etiology, Small Cell Lung Carcinoma complications
Abstract

Pancytopenia can be caused by lack of bone marrow function and can have different origins. A 66-year-old woman was admitted with severe sepsis, and the blood results revealed pancytopenia. A bone marrow biopsy was performed, and the primary diagnosis was hypocellular acute myeloid leukaemia with 20% blasts, but a diagnosis of myelodysplastic syndrome (MDS) was considered. After 30 days without any chemotherapeutic treatment her peripheral blood was normalised. In the meanwhile she was diagnosed with a small cell lung cancer. In this case the MDS-like condition was caused by a paraneoplastic phenomenon to the undiagnosed lung tumour.

Published
2014

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