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Objective: Gastroesophageal reflux disease (GERD) is believed to be one of the most common complications of congenital heart disease (CHD) in infants though the exact prevalence is not known. In this study, we aimed to investigate GERD symptoms in infants with CHD. Material and Methods: Infant Gastroesophageal Reflux Questionnaire Revised was applied twice for 109 infants with CHD and 81 healthy infants, both with a median age of 5 months, two months apart and data were analyzed. Results: Mean reflux score was 4.81±0.56 (0-23) and 5.1±5.71 (0-24) in the CHD and control groups, respectively (p=0.62). According to ROC curve analysis, we considered a score of 7 (95% CI=53%-76.6%) as being a cut-off value for GERD. Thirteen infants, 7 with CHD (6.42%) and 6 healthy infants (7.40%) had reflux score≥16 (p==0.79). Conclusion: GERD is not more common in CHD than in healthy babies. As the only difference in terms of individual symptom prevalence is in apnea and cyanosis, symptoms of CHD as well, it was concluded that there is a need for more objective methods and new questionnaires to be used for infants with CHD. [ABSTRACT FROM AUTHOR]