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2 results on '"Silvia Ancona"'

1. Biochemical and cytochemical effects of cytosine arabinoside (ARA C) and hydrocortisone on HeLa cells

Author

Maria Teresa Barberio, Paolo Adami, Paolo Rizzotti, Roberto Poltronieri, and Silvia d'Ancona

Subjects
Cancer Research, Hydrocortisone, Cell, 030218 nuclear medicine & medical imaging, HeLa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Enzyme inducer, chemistry.chemical_classification, Cell Nucleus, biology, Chemistry, Cytarabine, food and beverages, General Medicine, biology.organism_classification, Alkaline Phosphatase, Molecular biology, In vitro, carbohydrates (lipids), medicine.anatomical_structure, Enzyme, Oncology, 030220 oncology & carcinogenesis, Enzyme Induction, biology.protein, Alkaline phosphatase, Cytosine, Cell Division, medicine.drug, HeLa Cells
Abstract

The biochemical and cytochemical effects of cytosine arabinoside (Ara C) and of hydrocortisone on HeLa cells in vitro have been studied. In cultures treated with Ara C, a relationship exists between the cytocidal effects of the drug and an increase in alkaline phosphatase. Although hydrocortisone had no influence on the proliferative rhythm, it induced an increase in alkaline phosphatase. Results obtained with the cytochemical technique were evaluated, particularly in relation to enzyme localization.

Published
1979

2. [Development of epidermal tumors in mice painted with methylcholanthrene and injected with homologous skin suspensions]

Author

Silvia d'Ancona, Roberto Revoltella, and A. Corsi

Subjects
Cancer Research, Skin Neoplasms, medicine.medical_treatment, Freund's Adjuvant, medicine.disease_cause, Serology, chemistry.chemical_compound, Mice, medicine, Homologous chromosome, Animals, Carcinogen, integumentary system, biology, Cancer, General Medicine, Neoplasms, Experimental, medicine.disease, Molecular biology, Oncology, chemistry, Methylcholanthrene, Antibody Formation, biology.protein, Antibody, Carcinogenesis, Adjuvant
Abstract

Injections of homologous skin suspensions in Freund's adjuvant appreciably increased the carcinogenic effect of methylcholanthrene. Four months after the first painting with methylcholanthrene, cancer was present in 11 of 16 mice injected with skin suspension, whereas only 4 of the 18 non injected mice had cancer. Serological tests demonstrated the presence of antiskin antibodies in the injected animals. The results seem to indicate that immunological mechanisms may be involved in skin carcinogenesis.

Published
1966

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