1. Stage-dependent changes of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in colorectal cancer
- Author
-
Lu Lin, Dedong Chen, Xingming Ye, Yan Chen, Lin Wang, Ying Chen, Markus Dettke, Jing Jia, and Xiongwei Zheng
- Subjects
Adult ,Blood Platelets ,Male ,Pathology ,medicine.medical_specialty ,Neutrophils ,Colorectal cancer ,Lymphocyte ,Gastroenterology ,Disease-Free Survival ,Metastasis ,Leukocyte Count ,Carcinoembryonic antigen ,Internal medicine ,medicine ,Humans ,Lymphocytes ,Stage (cooking) ,Neutrophil to lymphocyte ratio ,Aged ,Neoplasm Staging ,Whole blood ,Aged, 80 and over ,biology ,Platelet Count ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,biology.protein ,Female ,Colorectal Neoplasms ,business - Abstract
This study aims to assess the association of the preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with tumor stage in colorectal cancer (CRC) patients. A retrospective study was performed in 336 CRC patients. Preoperative whole blood counts, serum levels of carcinoembryonic antigen (CEA), and clinicopathologic data were collected. The correlations between laboratory parameters and the tumor, node, and metastasis (TNM) stages were analyzed. The clinicopathologic TNM stages among CRC patients were 12.8 % at stage I, 32.4 % at stage II, 44.6 % at stage III, and 10.1 % at stage IV. NLR, PLR, and CEA levels were higher in CRC patients compared to healthy controls (all P
- Published
- 2015
- Full Text
- View/download PDF