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25 results on '"Rogers, Chris"'

3. Delivering COVID-19 vaccine trials at speed: the implementation of a phase IV UK multi-centre randomised controlled trial to determine safety and immunogenicity of COVID-19 vaccines co-administered with seasonal influenza vaccines (ComFluCOV)

Author

Baos, Sarah, Todd, Rachel, Thirard, Russell, Harris, Rosie, Kirwan, Jana, Joyce, Katherine, Hutton, David, Finn, Adam, Clout, Madeleine, Cappel-Porter, Heike, Rogers, Chris A, Lazarus, Rajeka, and Culliford, Lucy

Published
2024
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13. Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework

Author

Wilson, Caroline, Rooshenas, Leila, Paramasivan, Sangeetha, Elliott, Daisy, Jepson, Marcus, Strong, Sean, Birtle, Alison, Beard, David J., Halliday, Alison, Hamdy, Freddie C., Lewis, Rebecca, Metcalfe, Chris, Rogers, Chris A., Stein, Robert C., Blazeby, Jane M., and Donovan, Jenny L.

Subjects
medicine.medical_specialty, Endpoint Determination, Process (engineering), Clinical Decision-Making, Trial protocol, Eligibility Determination, Medicine (miscellaneous), Randomised controlled trials, BTC (Bristol Trials Centre), Non-participation, Eligibility assessment, 03 medical and health sciences, 0302 clinical medicine, Informed consent, Intervention (counseling), CONSORT statement, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Screening logs, Randomized Controlled Trials as Topic, lcsh:R5-920, business.industry, Patient Selection, Methodology, Consolidated Standards of Reporting Trials, Test (assessment), Patient recruitment, Treatment Outcome, Centre for Surgical Research, Sample Size, 030220 oncology & carcinogenesis, Screening, Physical therapy, BRTC, Recruitment, lcsh:Medicine (General), business
Abstract

BackgroundResearch has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. This article presents the development of a simple framework to document, understand and improve the process of trial recruitment. MethodsEight RCTs integrated a QuinteT Recruitment Intervention (QRI) into the main trial, feasibility or pilot study. Part of the QRI required mapping the patient recruitment pathway using trial-specific screening and recruitment logs. A content analysis compared the logs to identify aspects of the recruitment pathway and process that were useful in monitoring and improving recruitment. Findings were synthesised to develop an optimised simple framework that can be used in a wide range of RCTs. ResultsThe eight trials recorded basic information about patients screened for trial participation and randomisation outcome. Three trials systematically recorded reasons why an individual was not enrolled in the trial, and further details why they were not eligible or approached, or declined randomisation. A framework to facilitate clearer recording of the recruitment process and reasons for non-participation was developed: SEAR – Screening, to identify potentially eligible trial participants; Eligibility, assessed against the trial protocol inclusion/exclusion criteria; Approach, the provision of oral and written information and invitation to participate in the trial, and Randomised or not, with the outcome of randomisation or treatment received. ConclusionsThe SEAR framework encourages the collection of information to identify recruitment obstacles and facilitate improvements to the recruitment process. SEAR can be adapted to monitor recruitment to most RCTs, but is likely to add most value in trials where recruitment problems are anticipated or evident. Further work to test it more widely is recommended.

Published
2018

14. Platelet inhibition during ticagrelor monotherapy versus ticagrelor plus aspirin in patients with coronary artery disease (TEMPLATE study): study protocol for a randomised controlled trial

Author

Baos, Sarah, primary, Underwood, Wendy, additional, Culliford, Lucy, additional, Reeves, Barnaby C., additional, Rogers, Chris A., additional, Bowles, Ruth, additional, Johnson, Tom, additional, Baumbach, Andreas, additional, and Mumford, Andrew, additional

Published
2017
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17. Comparing different dosing regimens of bevacizumab in the treatment of neovascular macular degeneration: study protocol for a randomised controlled trial

Author

Foss, Alexander JE, primary, Childs, Margaret, additional, Reeves, Barnaby C, additional, Empeslidis, Theo, additional, Tesha, Paul, additional, Dhar-Munshi, Sushma, additional, Mughal, Samah, additional, Culliford, Lucy, additional, Rogers, Chris A, additional, Tan, Wei, additional, and Montgomery, Alan, additional

Published
2015
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19. A mixed-methods feasibility and external pilot study to inform a large pragmatic randomised controlled trial of the effects of surgical wound dressing strategies on surgical site infections (Bluebelle Phase B): study protocol for a randomised controlled trial.

Author

Reeves, Barnaby C., Andronis, Lazaros, Blazeby, Jane M., Blencowe, Natalie S., Calvert, Melanie, Coast, Joanna, Draycott, Tim, Donovan, Jenny L., Gooberman-Hill, Rachael, Longman, Robert J., Magill, Laura, Mathers, Jonathan M., Pinkney, Thomas D., Rogers, Chris A., Rooshenas, Leila, Torrance, Andrew, Welton, Nicky J., Woodward, Mark, Ashton, Kate, and Bera, Katarzyna D.

Subjects
RANDOMIZED controlled trials, SURGICAL site, SURGICAL dressings, WOUND care, ABDOMINAL surgery, ADHESIVES in surgery, CESAREAN section, COMPARATIVE studies, EXPERIMENTAL design, RESEARCH methodology, MEDICAL cooperation, RESEARCH protocols, RESEARCH, RESEARCH funding, SUTURING, SURGICAL site infections, TIME, WOUND healing, PILOT projects, EVALUATION research, TREATMENT effectiveness, DIAGNOSIS, THERAPEUTICS, PREVENTION
Abstract

Background: Surgical site infections (SSIs) are common, occurring in up to 25% of > 4 million operations performed in England each year. Previous trials of the effect of wound dressings on the risk of developing a SSI are of poor quality and underpowered.Methods/design: This study is a feasibility and pilot trial to examine the feasibility of a full trial that will compare simple dressings, no dressing and tissue-glue as a dressing. It is examining the overall acceptability of trial participation, identifying opportunities for refinement, testing the feasibility of and validating new outcome tools to assess SSI, wound management issues and patients' wound symptom experiences. It is also exploring methods for avoiding performance bias and blinding outcome assessors by testing the feasibility of collecting wound photographs taken in theatre immediately after wound closure and, at 4-8 weeks after surgery, taken by participants themselves or their carers. Finally, it is identifying the main cost drivers for an economic evaluation of dressing types. Integrated qualitative research is exploring acceptability and reasons for non-adherence to allocation. Adults undergoing primary elective or unplanned abdominal general surgery or Caesarean section are eligible. The main exclusion criteria are abdominal or other major surgery less than three months before the index operation or contraindication to dressing allocation. The trial is scheduled to recruit for nine months. The findings will be used to inform the design of a main trial.Discussion: This pilot trial is the first pragmatic study to randomise participants to no dressing or tissue-glue as a dressing versus a simple dressing. Early evidence from the ongoing pilot shows that recruitment is proceeding well and that the interventions are acceptable to participants. Combined with the qualitative findings, the findings will inform whether a main, large trial is feasible and, if so, how it should be designed.Trial Registration: ISRCTN49328913 . Registered on 20 October 2015. [ABSTRACT FROM AUTHOR]

Published
2017
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20. The By-Band study: gastric bypass or adjustable gastric band surgery to treat morbid obesity: study protocol for a multi-centre randomised controlled trial with an internal pilot phase

Author

Rogers, Chris A, primary, Welbourn, Richard, additional, Byrne, James, additional, Donovan, Jenny L, additional, Reeves, Barnaby C, additional, Wordsworth, Sarah, additional, Andrews, Robert, additional, Thompson, Janice L, additional, Roderick, Paul, additional, Mahon, David, additional, Noble, Hamish, additional, Kelly, Jamie, additional, Mazza, Graziella, additional, Pike, Katie, additional, Paramasivan, Sangeetha, additional, Blencowe, Natalie, additional, Perkins, Mary, additional, Porter, Tanya, additional, and Blazeby, Jane M, additional

Published
2014
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25. Documentation of adverse events in noncommercial trials of intravitreal injection of anti-VEGF drugs to treat wet age-related macular degeneration (AMD).

Author

Reeves, Barnaby C., Underwood, Wendy, Cappel-Porter, Heike, Baos, Sarah, Rogers, Chris A., Arnott, Michael, Harding, Simon P., Chakravarthy, Usha, and Foss, Alex E.

Subjects
CLINICAL medicine, RETINAL degeneration
Abstract

An abstract of the article "Documentation of adverse events in noncommercial trials of intravitreal injection of anti-VEGF drugs to treat wet age-related macular degeneration (AMD)," by Barnaby C. Reeves and colleagues, is presented.

Published
2011
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