1. Climbing Brain Levels of Organisation from Genes to Consciousness
- Author
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Jean-Pierre Changeux, CNRS UMR3571, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], Collège de France (CdF (institution)), This paper received funding from the European Union's Horizon 2020 research and innovation programmeunder grant agreement No 720270 (HBP SGA1) and SCR 130008 0, 1UE 64102 (HBP ramp up), European Project: 720270,H2020 Pilier Excellent Science,H2020-Adhoc-2014-20,HBP SGA1(2016), and Institut Pasteur [Paris] (IP)
- Subjects
0301 basic medicine ,Consciousness ,Cognitive Neuroscience ,media_common.quotation_subject ,Brain ,Gene Expression Regulation, Developmental ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Experimental and Cognitive Psychology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neuropsychology and Physiological Psychology ,Climbing ,Gene Regulatory Networks ,Psychology ,Neuroscience ,Gene ,030217 neurology & neurosurgery ,Transcription Factors ,media_common ,Epigenesis - Abstract
International audience; Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner.
- Published
- 2017