1. Bispecific antibodies: advancing precision oncology.
- Author
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Herrera M, Pretelli G, Desai J, Garralda E, Siu LL, Steiner TM, and Au L
- Subjects
- Humans, Drug Resistance, Neoplasm immunology, Drug Resistance, Neoplasm drug effects, Animals, Antineoplastic Agents, Immunological therapeutic use, Antineoplastic Agents, Immunological pharmacology, Molecular Targeted Therapy methods, Antibodies, Bispecific therapeutic use, Antibodies, Bispecific pharmacology, Antibodies, Bispecific immunology, Precision Medicine methods, Neoplasms immunology, Neoplasms therapy, Neoplasms drug therapy
- Abstract
Bispecific antibodies (bsAbs) are engineered molecules designed to target two different epitopes or antigens. The mechanism of action is determined by the bsAb molecular targets and structure (or format), which can be manipulated to create variable and novel functionalities, including linking immune cells with tumor cells, or dual signaling pathway blockade. Several bsAbs have already changed the treatment landscape of hematological malignancies and select solid cancers. However, the mechanisms of resistance to these agents are understudied and the management of toxicities remains challenging. Herein, we review the principles in bsAb engineering, current understanding of mechanisms of action and resistance, data for clinical application, and provide a perspective on ongoing challenges and future developments in this field., Competing Interests: Declaration of interests None declared by authors., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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