1. Pseudo-Orthostatic Tremor in Graves' Disease: A Possible Early Sign of Parkinsonism?
- Author
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Comolli D, Regalbuto S, Arceri S, Trifirò G, Calculli A, Fazio C, Grillo P, Todisco M, and Pisani A
- Subjects
- Humans, Male, Aged, Antithyroid Agents therapeutic use, Methimazole therapeutic use, Graves Disease complications, Graves Disease diagnosis, Graves Disease physiopathology, Tremor physiopathology, Tremor etiology, Tremor diagnosis, Parkinsonian Disorders physiopathology, Parkinsonian Disorders diagnostic imaging, Parkinsonian Disorders diagnosis, Parkinsonian Disorders complications
- Abstract
Background: Pseudo-orthostatic tremor is a hyperkinetic movement disorder usually associated with other neurological comorbidities, mainly Parkinson's disease., Case Report: A 65-year-old male presented with unsteadiness and leg tremor while standing. Electrophysiological evaluation confirmed the presence of pseudo-orthostatic tremor. Blood test showed an undiagnosed Graves' disease. A complete remission of tremor was achieved with methimazole. Dopamine transporter scintigraphy showed a mild reduction of the striatal binding, bilaterally., Discussion: Graves' disease can be associated with pseudo-orthostatic tremor. Thyroid function should be assessed in patients complaining of unsteadiness. The causative role of hyperthyroidism in determining dopaminergic degeneration and uncovering subclinical parkinsonism warrants further investigations., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2024 The Author(s).)
- Published
- 2024
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