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Atypical femoral fractures (AFFs) occur with minor trauma and are believed to be a potential complication of the prolonged use of antiresorptive agents, such as bisphosphonate and denosumab, for the treatment of bone metastasis. In comparison with typical femoral fractures, AFFs have a higher incidence of complications, including implant failure and delayed union or nonunion. This report describes the case of a 42-year-old woman who developed denosumab-associated AFF after denosumab therapy for bone metastasis from breast cancer. Surgical treatment with IMN was performed after open anatomical reduction. To reduce the risk of delayed union and nonunion, the autogenous bone graft obtained from the iliac crest was conducted. The radiograph taken 5 weeks after surgery showed callus formation. Full weight bearing was allowed 3 months after surgery. Six months postoperatively, radiographs and computed tomography images demonstrated bone union. Twelve months after surgery, the patient was able to walk easily without pain. For cancer patients with bone metastasis whose life expectancy may be limited, a decline in physical activity can be fatal. Consequently, it is crucial to avoid a decrease in activities of daily living brought about by delayed union or nonunion. In this regard, autogenous bone grafting is a viable and effective technique for the treatment of AFFs in patients with bone metastases., Competing Interests: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (© 2024 The Authors. Published by Elsevier Ltd.)

Atypical femoral fractures (AFF) are more difficult to treat than typical femoral fractures; they require strong fixation and good reduction. Intramedullary (IM) nailing is the first option for the treatment of complete AFF; however, there are few reports comparing IM nailing and extramedullary fixation. Moreover, there are no reports on the outcomes of bilateral atypical subtrochanteric femoral fractures treated with an IM nail on one side and a compression hip screw (CHS) on the other. We report the case of a 69-year-old woman who had been on risedronate sodium once a month since she was 58 years old. She reportedly felt pain in both her thighs due to an undiagnosed cause. Six months later, she fell and was diagnosed with bilateral complete atypical femoral subtrochanteric fractures (right side: Seinsheimer type IIC; left side: Seinsheimer type IIA). Four days later, she underwent CHS on the right side and IM nailing after open reduction surgery on the left. The reduction was successful. The left side healed 6 months after surgery, but the right side healed only after 14 months, despite assistance with low-intensity pulsed ultrasound. In atypical femoral subtrochanteric fractures, good reduction is important for healing, but, in this case, the CHS side healed slowly despite achievement of good reduction because of the difference in the fixation force between IM nailing and CHS, in addition to a probable occurrence of severely suppressed bone turnover (SSBT). Furthermore, reaming was not done on the CHS side, which may have contributed to the delay in bony union. IM nailing is the first option for atypical femoral subtrochanteric fractures because of faster union and lower reoperation rate than extramedullary fixation. Based on our findings, we recommend IM nailing as the first option for atypical femoral subtrochanteric fractures when good reduction can be achieved., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that have influenced the work reported in this paper., (© 2022 The Authors. Published by Elsevier Ltd.)

Intramedullary or cephalomedullary nail removal often is performed during nonunion reoperations. We have experienced a rare case in which it was difficult to remove the lag screw of the antegrade intramedullary nail, requiring a large amount of force to be applied over a long period. Removal of the lag screw is essential for removal of the nail and subsequent revision surgery. In our case, the lag screw could be removed only by cutting the screw with a carbide drill. For cases in which the nail and lag screw are firmly fixed, surgeons should prepare for the possibility of their separation using a carbide drill. Written informed consent was obtained from the patient for publication of this case report and accompanying images., (© 2021 The Authors.)

Introduction: In recent years, it has been reported that periprosthetic femoral fractures in the form of atypical femoral fractures (AFFs) are found occasionally as difficult-to-treat conditions. To date, there have been no reports of interprosthetic femoral fractures (IPFFs) having the form of AFFs. We report a case of an atypical IPFF with breakage of the plate due to abnormal femoral alignment., Case Report: A 70-year-old woman was admitted. She underwent left knee replacement and left hemi-arthroplasty at ages 61 and 60. And she had been taking bisphosphonate for 5 years. A plain X-ray revealed IPFF. The fracture was a complete transverse fracture with circumscribed thickening of the lateral cortical bone ("beak sign") at the fracture site. She underwent surgery. A reversed condylar locking compression plate (LCP) was used for internal fixation. Subsequently, she could walk without particular pain. Five months after the operation, she heard the snap of a bone breaking, and had difficulty walking. Plain X-ray revealed a re-fracture of the fracture site and breakage of the plate at the same high position. She underwent re-operation. A valgus osteotomy was performed at an angle of 15°. A reversed condylar LCP was used on the lateral side of the femur. A bone grafting was performed focusing on the fracture site. In addition, a short-LCP was fixed anteriorly to the femur. The bone union 1 year and 6 months postoperatively. She could walk, with no impairment being noted regarding ADL., Conclusions: We performed osteosynthesis for an IPFF having the characteristics of AFF, but the patient suffered breakage of the plate and re-fracture. Bone union was achieved as a result of re-operation that consisted of valgus osteotomy of the fracture site in combination with autologous bone grafting and double orthogonal plating., Competing Interests: The author(s) declare(s) no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© 2020 The Authors.)

Treatment using intramedullary nail (IMN) is challenging for atypical femoral incomplete fractures with the bowed femur. Although IMN is the first choice for atypical femoral fractures, there is often a mismatch between the shape of the femur and the implant. Therefore, for prophylactic surgery of atypical femoral incomplete fracture we used IMN with a chipping technique, which is used for non-unions of the longitudinal fracture. We report a case of an 87-year-old woman who presented with bilateral thigh pain that lasted 3 months and gradually worsened. She had a medication history of bisphosphonates for 10 years. In addition, radiography showed severe curvature in her femurs, with radiolucent fracture lines in the diaphysis. We obtained good results by using IMN with the chipping technique. Thigh pain was promptly relieved postoperatively. Four months after surgery, each bone had fused without the need for additional treatment. The chipping technique in prevention surgery of atypical femoral fracture can eliminate the mismatch with the implant by grinding the limited lesion, including the radiolucent fracture line. Moreover, it promotes bone healing., Competing Interests: None., (© 2020 The Author(s).)