1. Osteoporosis following heart transplantation and immunosuppressive therapy.
- Author
-
Löfdahl E and Rådegran G
- Subjects
- Absorptiometry, Photon methods, Bone Density, Diphosphonates administration & dosage, Female, Fractures, Spontaneous diagnostic imaging, Fractures, Spontaneous epidemiology, Graft Rejection prevention & control, Graft Survival, Heart Transplantation methods, Humans, Immunosuppressive Agents therapeutic use, Male, Osteoporosis diagnostic imaging, Osteoporosis drug therapy, Prognosis, Risk Assessment, Severity of Illness Index, Heart Transplantation adverse effects, Immunosuppressive Agents adverse effects, Osteoporosis chemically induced, Transplantation Immunology drug effects
- Abstract
Heart transplantation (HT) remains the ultimate final therapy for patients with end-stage heart failure, who despite optimal medical and surgical treatments exhibit severe symptoms. To prevent rejection of the transplanted organ, HT patients require life-long immunosuppressive therapy. The goal of the immunosuppression is to minimise the risk of immune-mediated graft rejection, while avoiding clinical side-effects. Current immunosuppressive agents have yielded good survival outcome, however, complications of the immunosuppressive therapy, such as impaired bone strength and increased fracture risk, are common among HT patients rendering increased morbidity and mortality rates. The main aim of the present review was to summarise current knowledge on bone strength impairment after HT and concomitant immunosuppressive therapy., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
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