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16. Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation: A Pooled Analysis of Two Large, Randomized, Controlled Trials

Author

Krämer, B.K., primary, Albano, L., additional, Banas, B., additional, Charpentier, B., additional, Bäckman, L., additional, Tedesco-Silva, H., additional, Lehner, F., additional, Mondragón-Ramírez, G.A., additional, Glyda, M., additional, Cassuto-Viguier, E., additional, Viklický, O., additional, Mourad, G., additional, Rigotti, P., additional, Schleibner, S., additional, and Kamar, N., additional

Published
2017
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24. Physical Activity in Solid Organ Transplant Recipients: Organizational Aspects and Preliminary Results of the Italian Project

Author

Roi, G.S., primary, Stefoni, S., additional, Mosconi, G., additional, Brugin, E., additional, Burra, P., additional, Ermolao, A., additional, Granito, M., additional, Macini, P., additional, Mastrosimone, S., additional, Nacchia, F., additional, Pegoraro, C., additional, Rigotti, P., additional, Sella, G., additional, Sgarzi, S., additional, Tamè, M.R., additional, Totti, V., additional, Trerotola, M., additional, Tripi, F., additional, and Nanni Costa, A., additional

Published
2014
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28. Nonadherent Behaviors After Solid Organ Transplantation

Author

Germani, G., primary, Lazzaro, S., additional, Gnoato, F., additional, Senzolo, M., additional, Borella, V., additional, Rupolo, G., additional, Cillo, U., additional, Rigotti, P., additional, Feltrin, G., additional, Loy, M., additional, Martin, A., additional, Sturniolo, G.C., additional, and Burra, P., additional

Published
2011
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40. Biphasic behavior of the kinetics of 31P-containing metabolites in ischemic porcine kidneys

Author

Corazza, A., Vianello, F., Rigo, A., Cadrobbi, R., Baldan, N., Rigotti, P., and Scarpa, M.

Subjects
*KIDNEY transplantation, *MAGNETIC resonance imaging, *METABOLISM, *ISCHEMIA
Abstract

The assessment of kidney viability before transplantation (with a view of discarding nonviable organs) remains an obstacle to confidently extending organ harvesting to marginal donors. In the present study phosphorus magnetic resonance spectroscopy was used to monitor metabolic changes in 31P-containing metabolites in isolated porcine kidneys. After various warm ischemia times, the organs were stored at 0°C. Time-dependent changes in the phosphomonoester/inorganic-phosphate ratio were recorded at 0°C were shown to follow a biexponential decay. The first-order kinetic rate constant of the short-time decay was strongly dependent on the warm ischemia time, a result that was discreted in terms of the underlying biochemistry. The metabolic events responsible for the dramatic decrease in phosphomonoester/inorganic phosphate ratio that occur immediately after organ perfusion and storage, suggest that any procedure to minimize organ damage must occur immediately after harvesting. [Copyright &y& Elsevier]

Published
2003
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41. Blood Cyclosporine Level Soon After Kidney Transplantation is a Major Determinant of Rejection: Insights From the Mycophenolate Steroid-Sparing Trial

Author

D. Donati, G. Segoloni, Borislav D. Dimitrov, S. Sandrini, Bogdan Ene Iordache, G. Remuzzi, G. Mourad, Flavio Gaspari, Mariadomenica Lesti, Dario Cattaneo, S. Federico, P. Rigotti, J.-L. Bosmans, V. Sparacino, N. Perico, Eliana Gotti, Piero Ruggenenti, U. Valente, M. Salvadori, Gotti, E, Perico, N, Gaspari, F, Cattaneo, D, Lesti, Md, Ruggenenti, P, Segoloni, G, Salvadori, M, Rigotti, P, Valente, U, Donati, D, Sandrini, S, Federico, Stefano, Sparacino, V, Mourad, G, Bosmans, Jl, Dimitrov, Bd, Iordache, Be, and Remuzzi, G.

Subjects
Graft Rejection, Male, Mycophenolate Mofetil, medicine.medical_specialty, medicine.drug_class, Biopsy, T-Lymphocytes, Urinary system, Urology, Rejection, Statistics, Nonparametric, Mycophenolic acid, Humans, Kidney Transplantation, Cyclosporine, Mycophenolate Steroid Sparing Trial, Pharmacokinetics, Adrenal Cortex Hormones, medicine, Kidney transplantation, Analysis of Variance, Clinical Trials as Topic, Transplantation, Kidney, business.industry, Mycophenolic Acid, medicine.disease, Ciclosporin, Treatment Outcome, medicine.anatomical_structure, Area Under Curve, Creatinine, Multivariate Analysis, Immunology, cyclosporine level, Regression Analysis, Corticosteroid, Female, Surgery, Drug Monitoring, business, Immunosuppressive Agents, medicine.drug
Abstract

Target organs express antigens directly recognized by antigen-specific T cells, thereby precipitating rejection. When early T-cell activation is inhibited, there is a low risk of rejection. We sought to determine the predictive values of serial posttransplant blood cyclosporine trough (C(0)) concentrations to minimize the risk for a first rejection episode compared with 2-hour postdose (C(2)) drug concentrations. The final aim of the study was to identify a concentration range for the best predictive pharmacokinetic parameter that should be targeted to reduce the risk of rejection. This possibility was explored in 334 de novo kidney transplant recipients who participated in the prospective, multicenter Mycophenolate Steroid-Sparing Trial. Among measurements performed during the first 6 months postsurgery, cyclosporine C(0) levels measured early after transplantation were the strongest predictor of acute graft rejection. Levels within 300 to 440 ng/mL were associated with the lowest risk of rejection, while patients with levels lower than 300 ng/mL showed a more than double risk. Cyclosporine trough values predicted allograft rejection with an accuracy of 74%, while C(2) levels had no predictive value. These findings underline the need to target cyclosporine therapy early posttransplant to modulate T-cell activation.

Published
2005

42. How Long Does It Take to Acquire Mastery of Performance in Laparoscopic Living Donor Nephrectomy? A Center-Based and Surgeon-Based Operative Time CUSUM Analysis.

Author

Di Bella C, Capovilla G, Rosso E, Di Bello M, Tuci F, Contarini E, Simioni A, Baldan N, Silvestre C, Rigotti P, and Furian L

Subjects
Humans, Nephrectomy methods, Living Donors, Operative Time, Tissue and Organ Harvesting adverse effects, Length of Stay, Retrospective Studies, Laparoscopy adverse effects, Laparoscopy methods, Surgeons
Abstract

Background: The safety of laparoscopic donor nephrectomy (LDN) has been widely documented, but its challenging learning curve (LC) requires an insightful assessment to expand its application. The aim of this study was to evaluate LC of LDN in a high-volume transplant center., Methods: Three hundred forty-three LDNs performed from 2001 to 2018 were evaluated. CUSUM analysis based on the operative time was used to assess the number of cases required to reach mastery in the technique for both the entire surgical team and for the 3 main surgeons considered separately. Analysis of association between demographics, perioperative characteristics, and complications within the different LC phases was conducted., Results: Mean operative time was 228.9 minutes. Mean length of stay was 3.8 days and mean warm ischemia time (WIT) was 170.8 seconds. Surgical and medical complication rates were 7.3% and 6.4%, respectively. The CUSUM-LC showed a requirement of 157 cases (for surgical team) and 75 cases (for single surgeons) to reach competence in the procedure. Patient baseline characteristic showed no differences among the LC phases. Compared with the initial LC phase, hospital stay was significantly lower at the end of the LC whereas WIT results were longer in the LC descendent phase., Conclusions: This study confirms the safety and efficacy of LDN, with a low rate of complications. This analysis suggests that about 75 procedures are required to reach competence and 93 cases to achieve mastery level of skill for a single surgeon. It can be hypothesized that, in a high-volume transplant enter, the time to guarantee training in LDN is compatible with the duration of a clinical fellowship., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
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43. Lower Urinary Tract Symptoms in Kidney Transplant Recipients and Timing of Treatment With TURP: Impact on Renal Graft Survival and Function.

Author

Neri F, Di Bella C, Leone S, Bencini G, Silvestre C, Tuci F, Rigotti P, and Furian L

Subjects
Aged, Graft Survival, Humans, Lower Urinary Tract Symptoms epidemiology, Lower Urinary Tract Symptoms etiology, Lower Urinary Tract Symptoms surgery, Male, Middle Aged, Prostatic Hyperplasia epidemiology, Urinary Bladder Neck Obstruction epidemiology, Urinary Bladder Neck Obstruction etiology, Urinary Bladder Neck Obstruction surgery, Kidney Transplantation adverse effects, Prostatic Hyperplasia complications, Prostatic Hyperplasia surgery, Transurethral Resection of Prostate
Abstract

Background: With the aging of recipients of renal transplantation (RT) one of the emerging issues is the incidence of low urinary tract symptoms (LUTS), which may have negative consequences on the graft survival and function. The aim of our study was to assess the influence of LUTS and the treatment with transurethral resection of the prostate (TURP) on the outcome of RT., Materials and Methods: We collected data from men over 55 who underwent RT at our center from January 2007 to December 2016. We analyzed the incidence of LUTS; the rate of treatment with TURP; the eGFR (estimated glomerular filtration rate) at 6 months and 1, 3, and 5 years from transplantation; and graft survival., Results: Fifty-five patients out of 268 experienced LUTS, and 19 of them had a bladder outlet obstruction (BOO). Patients experiencing BOO had a significantly higher hazard ratio (HR) of graft failure (HR 5.7, CI 1.56-21.4) compared to the other recipients. Of the 18 patients treated with TURP, 10 received the procedure within 6 months from the LUTS onset. They had a significantly absolute eGFR improvement at 6 months from the intervention (+14.25 mL/min ± 8.10) compared to the patients treated later (-8.4 mL/min ± 14.43)., Discussion: We showed the negative effects of LUTS on kidney graft function and survival. Although TURP is the standard therapy for such an issue, the best timing for it still has to be defined. Our experience supports the need for an early treatment of the LUTS for promoting the outcome of the RT., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
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44. Prevention of renal ischemic damage by endothelial protecting agents.

Author

Rigotti P, Ferraresso M, Morpurgo E, Cadrobbi R, Menon F, Bacelle L, Calabrese F, Valente ML, Gatta A, and Ancona E

Subjects
Animals, Arginine administration & dosage, Blood Urea Nitrogen, Creatinine blood, Glomerular Filtration Rate drug effects, Infusions, Intravenous, Injections, Intravenous, Kidney drug effects, Kidney pathology, Kidney Function Tests, Oligodeoxyribonucleotides administration & dosage, Swine, Urination, p-Aminohippuric Acid, Arginine pharmacology, Endothelium, Vascular drug effects, Ischemia physiopathology, Kidney blood supply, Oligodeoxyribonucleotides pharmacology
Published
1995

45. Pre- and postoperative evaluation of vascular resistance in living related renal allografts under cyclosporine infusion.

Author

Rigotti P, Sacerdoti D, Bolognesi M, Bombonato GC, Capalbo M, Ferraresso M, Di Landro D, Antonello A, Nolli ML, and Gatta A

Subjects
Adolescent, Adult, Blood Pressure drug effects, Cyclosporine administration & dosage, Humans, Infusions, Intravenous, Kidney diagnostic imaging, Kidney Transplantation immunology, Male, Middle Aged, Nuclear Family, Tissue Donors, Transplantation, Homologous, Ultrasonography, Vascular Resistance drug effects, Cyclosporine therapeutic use, Kidney Transplantation physiology, Vascular Resistance physiology
Published
1994

46. UW vs Euro-Collins solution in preserving warm ischemia-damaged kidneys.

Author

Rigotti P, Capalbo M, Baldan N, Ganz E, Cadrobbi R, Pittoni G, Rasia Dani E, Valente ML, and Ancona E

Subjects
Adenosine, Allopurinol, Animals, Blood Urea Nitrogen, Creatinine blood, Glutathione, Insulin, Kidney Transplantation pathology, Kidney Tubular Necrosis, Acute pathology, Kidney Tubules, Proximal pathology, Kidney Tubules, Proximal ultrastructure, Microscopy, Electron, Microvilli ultrastructure, Raffinose, Swine, Transplantation, Autologous, Hypertonic Solutions, Ischemia, Kidney blood supply, Kidney Transplantation physiology, Organ Preservation methods, Organ Preservation Solutions
Published
1993

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