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103 results on '"Dubernard, J M."'

8. Human hand transplantation: what have we learned?

Author

Lanzetta M, Petruzzo P, Vitale G, Lucchina S, Owen ER, Dubernard JM, Hakim N, and Kapila H

Subjects
Adolescent, Adult, Cadaver, Humans, Magnetic Resonance Imaging, Middle Aged, Tissue Donors, Transplantation, Homologous methods, Treatment Outcome, Hand Transplantation
Abstract

Hand transplantation may become an important procedure for upper limb functional restoration. To date, 18 patients have been undergone 24 hand operations in the world. Initial results are extremely promising; the functional results are apparently superior to those obtained with prostheses. We report on the combined French and Italian experience of six patients (eight hands), which is based on a jointly devised protocol and represents the largest available clinical series. Six male patients aged 43, 33, 35, 32, 33, and 22 years received either a single right hand-dominant transplantation (four cases) or a simultaneous double hand transplantation (two cases). The time since the amputation ranged from 3 to 22 years. The level of transplantation was at the wrist in five cases (six hands) and at the distal forearm in two cases (two hands). Cold ischemia averaged 11.5 hours. Three patients simultaneously received additional full-thickness skin taken from the donor and transplanted onto their left hip area. This skin served as a source for biopsies and as an additional area to monitor rejection (distant sentinel skin graft). The immunosuppressive protocol included polyclonal antibodies (three patients) or monoclonal anti-CD 25 antibody (three patients), tacrolimus, mycophenolate mofetil, and prednisolone. No surgical complications occurred. Skin rejection occurred at least once in all patients at a mean of 40 days postoperatively. Three patients recovered protective and some discriminative sensation in their palm and fingers. Two patients are recovering sensation, but are still in the early phases of the regenerative process, due to the short time since the transplantation. One patient was not compliant with the immunosuppressive therapy, and underwent uncontrolled rejection and reamputation.

Published
2004
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9. Portal drainage of pancreas allograft: surgical complications and graft survival.

Author

Dawahra M, Petruzzo P, Lefrançois N, Thivolet C, Badet L, Dubernard JM, and Martin X

Subjects
Adult, Female, Humans, Laparotomy, Male, Middle Aged, Pancreas Transplantation physiology, Portal System, Transplantation, Homologous methods, Transplantation, Homologous physiology, Graft Survival, Intraoperative Complications surgery, Pancreas Transplantation methods, Portal Vein surgery
Published
2002
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11. Immunosuppression in composite tissue allografts.

Author

Petruzzo P, Lefrançois N, Kanitakis J, Gebuhrer L, Da Silva M, Konan PG, Dawahra M, Martin X, Revillard JP, and Dubernard JM

Subjects
Animals, B-Lymphocytes immunology, Graft vs Host Disease immunology, Graft vs Host Disease prevention & control, Histocompatibility Testing, Humans, T-Lymphocytes immunology, Hand Transplantation, Immunosuppression Therapy methods, Transplantation, Homologous immunology
Published
2001
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12. Impact of the functioning pancreas on long-term renal function in pancreas-kidney transplantation.

Author

Lefrançois N, Petruzzo P, Sepeteanu I, Da Silva M, McGregor B, Dawahra M, Hadj-Aissa A, Dubernard JM, Touraine JL, and Martin X

Subjects
Albumins metabolism, Diabetic Nephropathies physiopathology, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney blood supply, Recurrence, Retrospective Studies, Diabetic Nephropathies surgery, Kidney physiology, Kidney Transplantation physiology, Pancreas Transplantation physiology
Published
2001
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13. Peripheral nerve regeneration in human hand transplantation.

Author

Owen ER, Dubernard JM, Lanzetta M, Kapila H, Martin X, Dawahra M, and Hakim NS

Subjects
Cadaver, Hand innervation, Hand Strength, Humans, Immunosuppressive Agents pharmacology, Male, Median Nerve drug effects, Median Nerve surgery, Middle Aged, Nerve Regeneration drug effects, Sensation, Tacrolimus pharmacology, Treatment Outcome, Ulnar Nerve drug effects, Ulnar Nerve surgery, Forearm innervation, Hand Transplantation, Median Nerve physiology, Nerve Regeneration physiology, Ulnar Nerve physiology
Published
2001
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15. Combined analysis of autoantibodies against beta-cells for prediction of pancreas allograft failure.

Author

Da Silva M, Thivolet C, Lefrançois N, Bosshard S, Sepeteanu I, Petruzzo P, Dubernard JM, and Martin X

Subjects
Diabetes Mellitus, Type 1 blood, Glutamate Decarboxylase immunology, Histocompatibility Antigens Class II immunology, Humans, Pancreas Transplantation methods, Predictive Value of Tests, Prognosis, Retrospective Studies, Transplantation, Homologous, Treatment Failure, Autoantibodies blood, Diabetes Mellitus, Type 1 immunology, Diabetes Mellitus, Type 1 surgery, Islets of Langerhans immunology, Pancreas Transplantation immunology
Published
2000
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16. Continent urinary cutaneous diversion in kidney transplantation: long-term results.

Author

Dawahra M, Fassi-Fehri H, Konan PG, Marechal JM, DaSilva M, Lefrançois N, Dubernard JM, and Martin X

Subjects
Adult, Bone Diseases, Metabolic, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Male, Osteoporosis, Postoperative Complications, Retrospective Studies, Time Factors, Transplantation, Homologous, Kidney Transplantation methods, Kidney Transplantation physiology, Urinary Diversion
Published
2000
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17. A randomized trial in simultaneous pancreas-kidney transplantation: portal versus systemic venous drainage of the pancreas allograft.

Author

Petruzzo P, Konan PG, Feitosa LC, Da Silva M, Touiti D, Lefrançois N, Dubernard JM, and Martin X

Subjects
Anastomosis, Surgical methods, Female, Graft Survival, Humans, Kidney Failure, Chronic etiology, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Kidney Transplantation mortality, Male, Pancreas Transplantation mortality, Portal Vein surgery, Survival Rate, Transplantation, Homologous, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Kidney Transplantation physiology, Pancreas Transplantation methods, Pancreas Transplantation physiology
Published
2000
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18. Impact of pancreas function on long-term renal function in simultaneous pancreas-kidney transplantation.

Author

Lefrançois N, Hadjaissa A, Petruzzo P, Da Silva M, Martin X, Dubernard JM, and Touraine JL

Subjects
Blood Glucose metabolism, Follow-Up Studies, Glomerular Filtration Rate, Glycated Hemoglobin analysis, Humans, Kidney Failure, Chronic etiology, Kidney Function Tests, Renal Circulation, Retrospective Studies, Time Factors, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Kidney Failure, Chronic surgery, Kidney Transplantation physiology, Pancreas Transplantation physiology
Published
2000
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19. Protective effect of an anti-LFA 1 monoclonal antibody (odulimomab) on renal damage due to ischemia and kidney autotransplantation.

Author

Martin X, Da Silva M, Virieux SR, Hadj Aissa A, Buffet R, Tiollier J, and Dubernard JM

Subjects
Animals, Glomerular Filtration Rate, Kidney Transplantation immunology, Lymphocyte Function-Associated Antigen-1 immunology, Macaca fascicularis, Organ Preservation, Transplantation, Autologous, Antibodies, Monoclonal therapeutic use, Immunosuppression Therapy, Ischemia, Kidney blood supply, Kidney Transplantation physiology
Published
2000
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20. Kidney-pancreas transplantation: our experience with systemic and portal drainage of pancreatic graft.

Author

Martin X, Dawahra M, Lefrançois N, Da Silva M, Petruzzo P, Pibiri L, Feitosa LC, and Dubernard JM

Subjects
Adult, Blood Glucose metabolism, C-Peptide analysis, Female, Humans, Insulin blood, Insulin metabolism, Insulin Secretion, Kidney Transplantation mortality, Kidney Transplantation physiology, Male, Middle Aged, Pancreas Transplantation mortality, Pancreas Transplantation physiology, Survival Rate, Anastomosis, Roux-en-Y, Kidney Transplantation methods, Pancreas Transplantation methods, Portal Vein surgery
Published
2000
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21. Long-term metabolic control and pancreatic graft survival according to surgical technique.

Author

Tajra LC, Dubernard JM, Dawhara M, Lefrancois N, Badet L, and Martin X

Subjects
Adult, Blood Glucose metabolism, C-Peptide metabolism, Diabetes Mellitus, Type 1 blood, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Insulin metabolism, Insulin Secretion, Male, Middle Aged, Retrospective Studies, Time Factors, Treatment Failure, Diabetes Mellitus, Type 1 surgery, Graft Survival, Pancreas Transplantation methods, Pancreas Transplantation physiology
Published
1999
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22. Future of pancreatic transplantation.

Author

Dubernard JM, Martin X, Lefrancois N, Dawahra M, and Feitosa LC

Subjects
Diabetic Nephropathies surgery, Humans, Immunosuppression Therapy methods, Immunosuppression Therapy trends, Kidney Transplantation, Pancreas Transplantation immunology, Pancreas Transplantation methods, Quality of Life, Diabetes Mellitus, Type 1 surgery, Pancreas Transplantation trends
Published
1999
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26. Autotransplantation of the kidney in primates: a model of renal damage to study the ischemia-reperfusion injury.

Author

Martin X, Da Silva M, Virieux RS, Daher I, Hadj-Aïssa A, Buffet R, Tiollier J, Zheng S, Guttmann R, and Dubernard JM

Subjects
Animals, Blood Pressure, Creatinine blood, Glomerular Filtration Rate, Kidney Transplantation pathology, Macaca fascicularis, Organ Preservation methods, Potassium metabolism, Sodium metabolism, Transplantation, Autologous, Kidney, Kidney Transplantation physiology, Reperfusion Injury
Published
1997
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29. Renal transplantation using continent urinary diversion: long-term follow-up.

Author

Dawahra M, Martin X, Tajra LC, Cloix P, Marechal JM, Garnier JL, and Dubernard JM

Subjects
Adult, Bacteriuria epidemiology, Bacteriuria etiology, Creatinine blood, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Time Factors, Urinary Bladder surgery, Kidney Transplantation methods, Kidney Transplantation physiology, Urinary Diversion methods
Published
1997
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30. Renal transplantation between spouses.

Author

Cloix P, Marrast AC, Lefrançois N, Garnier JL, Gebührer M, Martin X, Dubernard JM, and Touraine JL

Subjects
Adult, Female, Follow-Up Studies, Graft Rejection epidemiology, Humans, Male, Middle Aged, Time Factors, Graft Survival, Kidney Failure, Chronic surgery, Kidney Transplantation physiology, Living Donors, Spouses
Published
1996

31. Incidence of CMV infection in simultaneous pancreas and kidney transplantation: comparative study of two surgical procedures of segmental pancreas versus whole bladder-drained pancreas.

Author

Ishibashi M, Bosshard S, Fukuuchi F, Lefrancois N, Martin X, Touraine L, and Dubernard JM

Subjects
Humans, Pancreas Transplantation physiology, Time Factors, Urinary Bladder surgery, Cytomegalovirus Infections epidemiology, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Pancreas Transplantation methods, Postoperative Complications epidemiology
Published
1996

32. Absence of microchimerism in long-term tolerant living-donor kidney graft recipients.

Author

Garnier JL, Daoud S, Favre-Victoire I, Cozon G, Boulez J, Dubernard JM, Betuel H, Touraine JL, and Gebuhrer L

Subjects
Chimera, Exons, Female, Follow-Up Studies, Humans, Immunosuppressive Agents therapeutic use, Kidney Transplantation immunology, Living Donors, Male, Nuclear Family, Polymerase Chain Reaction, Time Factors, Y Chromosome, HLA-DQ Antigens genetics, HLA-DR Antigens genetics, Kidney Transplantation physiology, Transplantation Chimera
Published
1996

33. Comparative efficacy of prophylactic monoclonal (OKT3) and polyclonal antibodies (ATG) in immunologic high-risk renal transplant recipients.

Author

Fukuuchi F, Lefrançois N, Chapuis F, Gebuhrer L, Bosshard S, Dubernard JM, and Touraine JL

Subjects
Azathioprine therapeutic use, Chi-Square Distribution, Cyclosporine therapeutic use, Cytomegalovirus Infections epidemiology, Humans, Immunization, Immunosuppressive Agents therapeutic use, Kidney Neoplasms mortality, Methylprednisolone therapeutic use, Postoperative Complications, Prednisolone therapeutic use, Retrospective Studies, Survival Rate, Time Factors, Antilymphocyte Serum therapeutic use, Graft Survival, Immunosuppression Therapy methods, Kidney Neoplasms immunology, Muromonab-CD3 therapeutic use
Published
1996

34. Prevention of chronic rejection and puromycin-induced glomerulosclerosis in rats by gamma-lactone, an inhibitor of macrophage-effector activation.

Author

Ishibashi M, Azuma H, Margonari J, Revillard JP, Martin X, Dubernard JM, and Tilney NL

Subjects
Animals, Glomerulonephritis chemically induced, Graft Rejection pathology, Kidney Transplantation immunology, Kidney Transplantation pathology, Macrophage Activation, Male, Proteinuria, Rats, Rats, Inbred F344, Rats, Inbred Lew, Rats, Sprague-Dawley, Transplantation, Homologous, Furans pharmacology, Glomerulonephritis prevention & control, Graft Rejection prevention & control, Immunosuppressive Agents pharmacology, Kidney Transplantation physiology, Puromycin toxicity
Published
1996

35. Pancreatic transplantation.

Author

Dubernard JM, Rahbar M, Martin X, Laftavi MR, and Lefrancois N

Subjects
Anastomosis, Roux-en-Y, Diabetes Mellitus, Type 1 drug therapy, Duodenum, Graft Survival, Humans, Immunosuppression Therapy methods, Insulin Infusion Systems, Islets of Langerhans Transplantation, Pancreas Transplantation physiology, Postoperative Complications epidemiology, Randomized Controlled Trials as Topic, Retrospective Studies, Urinary Bladder, Diabetes Mellitus, Type 1 surgery, Pancreas Transplantation methods
Published
1995

36. Combined liver-kidney transplantation for primary hyperoxaluria: a report of two cases.

Author

Garnier JL, Boillot O, Gille D, Delafosse B, Colon S, Boujet C, Dubernard JM, and Touraine JL

Subjects
Adult, Biopsy, Female, Follow-Up Studies, Furosemide therapeutic use, Humans, Kidney Function Tests, Male, Renal Dialysis, Hyperoxaluria surgery, Kidney Transplantation pathology, Kidney Transplantation physiology, Liver Transplantation physiology
Published
1995

37. Hodgkin's disease after renal transplantation.

Author

Garnier JL, Lebranchu Y, Lefrançois N, Martin X, Dubernard JM, Berger F, and Touraine JL

Subjects
Adolescent, Adult, Follow-Up Studies, Herpesviridae Infections diagnosis, Herpesvirus 4, Human isolation & purification, Hodgkin Disease virology, Humans, Male, Neoplasm Staging, Reed-Sternberg Cells pathology, Reed-Sternberg Cells virology, Time Factors, Tumor Virus Infections diagnosis, Hodgkin Disease pathology, Kidney Transplantation, Postoperative Complications
Published
1995

38. Hepatitis C virus infection in renal transplantation.

Author

Daoud S, Garnier JL, Chossegros P, Chevallier P, Dubernard JM, and Touraine JL

Subjects
Azathioprine therapeutic use, Cyclosporine therapeutic use, Hepatitis C diagnosis, Hepatitis C drug therapy, Humans, Liver pathology, Liver virology, Pancreas Transplantation immunology, Polymerase Chain Reaction, Ribavirin therapeutic use, Hepatitis C epidemiology, Kidney Transplantation immunology, Postoperative Complications virology
Published
1995

39. Simultaneous adrenal gland and kidney allotransplantation after synchronous bilateral renal cell carcinoma: a case report.

Author

Dubernard JM, Cloix P, Tajra LC, Alduglihan W, Borson F, Lefrançois N, and Martin X

Subjects
Adrenal Cortex physiology, Adrenal Glands physiology, Adrenocorticotropic Hormone, Aldosterone blood, Antilymphocyte Serum therapeutic use, Autopsy, Azathioprine therapeutic use, Carcinoma, Renal Cell pathology, Carcinoma, Renal Cell radiotherapy, Carcinoma, Renal Cell secondary, Cyclosporine therapeutic use, Fatal Outcome, Humans, Hypophysectomy, Kidney Neoplasms pathology, Male, Middle Aged, Pituitary Neoplasms radiotherapy, Pituitary Neoplasms secondary, Pituitary Neoplasms surgery, Prednisone therapeutic use, Adrenal Glands transplantation, Carcinoma, Renal Cell surgery, Kidney Neoplasms surgery, Kidney Transplantation immunology, Kidney Transplantation pathology, Kidney Transplantation physiology, Transplantation, Homologous immunology, Transplantation, Homologous pathology, Transplantation, Homologous physiology
Published
1995

40. Diabetic polyneuropathy outcome after successful pancreas transplantation: 1 to 9 year follow up.

Author

Laftavi MR, Chapuis F, Vial C, Rahbar M, Lefrancois N, Feitosa LC, Dubernard JM, and Martin X

Subjects
Adult, Diabetes Mellitus, Type 1 physiopathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Neurons physiology, Neurons, Afferent physiology, Time Factors, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Diabetic Neuropathies physiopathology, Kidney Transplantation physiology, Neural Conduction, Pancreas Transplantation physiology
Published
1995

41. Early postoperative period: study of metabolic profiles after segmental or total pancreas transplantation.

Author

Tajra LC, Molina G, Albalate P, Lefrançois N, Brunet M, Martin X, and Dubernard JM

Subjects
Blood Glucose metabolism, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 drug therapy, Duodenum surgery, Duodenum transplantation, Humans, Insulin blood, Insulin therapeutic use, Postoperative Period, Time Factors, Urinary Bladder surgery, Diabetes Mellitus, Type 1 surgery, Pancreas Transplantation methods, Pancreas Transplantation physiology
Published
1994

42. Technical aspects of pancreas transplantation.

Author

Dubernard JM, Martin X, Lefrancois N, Cloix P, and Brunet M

Subjects
Duodenum surgery, Humans, Pancreas surgery, Tissue Donors, Pancreas Transplantation methods
Published
1994

43. Conversion of total bladder-drained pancreas into total injected grafts.

Author

Martin X, Jemni M, Lefrançois N, Laville M, Tajra LC, Molina G, Dawhara M, and Dubernard JM

Subjects
Drainage, Humans, Pancreatitis prevention & control, Reoperation, Retrospective Studies, Duodenum surgery, Pancreas Transplantation methods, Postoperative Complications surgery, Urinary Bladder surgery
Published
1994

44. Successful cadaveric renal transplantation in small children.

Author

Cochat P, Martin X, Floret D, Long D, Parchoux B, Castelo F, Dubernard JM, and David L

Subjects
Cadaver, Child, Child, Preschool, Female, Graft Survival, Hemolytic-Uremic Syndrome surgery, Humans, Infant, Kidney abnormalities, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects, Kidney Transplantation physiology, Male, Postoperative Complications etiology, Recurrence, Tissue Donors, Kidney Transplantation methods
Published
1994

47. Simultaneous transplantation of kidney and pancreas in diabetes patients.

Author

Dawahra M, Cloix P, Martin X, Abbar M, Marechal JM, and Dubernard JM

Subjects
Actuarial Analysis, Adult, Duodenum transplantation, Follow-Up Studies, Humans, Immunosuppressive Agents therapeutic use, Kidney Transplantation methods, Kidney Transplantation mortality, Pancreas Transplantation methods, Pancreas Transplantation mortality, Retrospective Studies, Survival Analysis, Time Factors, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Graft Survival, Kidney Transplantation physiology, Pancreas Transplantation physiology
Published
1993

48. Pancreas transplantation in the uremic patient: a random trial of total pancreas with bladder drainage versus duct obstruction of segmental grafts.

Author

Martin X, Lefrancois N, Dawhara M, Bret M, Brunet M, Desmettre O, Garnier JL, Pouteil-Noble C, and Dubernard JM

Subjects
Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies surgery, Glucose Tolerance Test, Glycated Hemoglobin analysis, Graft Rejection, Graft Survival, Humans, Kidney Transplantation immunology, Kidney Transplantation physiology, Neoprene therapeutic use, Pancreas Transplantation immunology, Pancreas Transplantation physiology, Postoperative Complications, Survival Analysis, Time Factors, Kidney Transplantation methods, Pancreas Transplantation methods, Uremia surgery, Urinary Bladder surgery
Published
1993

49. Pancreas transplantation: the choice of the best technique.

Author

Dubernard JM, Martin X, Lefrancois N, Dawahra M, Choukair M, Sousa-Castello A, Viguier JL, and Cloix P

Subjects
Follow-Up Studies, Graft Survival, Humans, Pancreas Transplantation adverse effects, Pancreas Transplantation physiology, Retrospective Studies, Time Factors, Pancreas Transplantation methods
Published
1992

50. Ophthalmologic follow-up of type I diabetic patients after kidney and pancreas transplantation.

Author

Zech JC, Trepsat C, Gain-Gueugnon M, Lefrançois N, Martin X, and Dubernard JM

Subjects
Adult, Cataract etiology, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Cataract physiopathology, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 1 surgery, Diabetic Nephropathies physiopathology, Diabetic Nephropathies surgery, Diabetic Retinopathy physiopathology, Kidney Transplantation physiology, Pancreas Transplantation physiology, Visual Acuity
Published
1992

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