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5. IN VITRO T CELL PROLIFERATION FROM KIDNEY ALLOGRAFT BIOPSIES WITH UNREMARKABLE PATHOLOGY

Author

Smith, Craig R., primary, Jaramillo, Andrés, additional, Poindexter, Nancy J., additional, Steward, Nancy S., additional, Lu, Kim C., additional, Brennan, Daniel C., additional, Singer, Gary G., additional, Miller, Brent W., additional, Jendrisak, Martin D., additional, Shenoy, Surendra, additional, Lowell, Jeffrey A., additional, Howard, Todd K., additional, and Mohanakumar, T., additional

Published
2002
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8. CADAVERIC VERSUS LIVING DONOR KIDNEY TRANSPLANTATION

Author

Smith, Craig R., primary, Woodward, Robert S., additional, Cohen, David S., additional, Singer, Gary G., additional, Brennan, Daniel C., additional, Lowell, Jeffrey A., additional, Howard, Todd K., additional, and Schnitzler, Mark A., additional

Published
2000
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15. IN SITU SPLITTING OF THE CADAVERIC LIVER FOR TRANSPLANTATION1

Author

Goss, John A., primary, Yersiz, Hasan, additional, Shackleton, Christopher R., additional, Seu, Philip, additional, Smith, Craig V., additional, Markowitz, Jay S., additional, Farmer, Douglas G., additional, Ghobrial, R. Mark, additional, Markmann, James F., additional, Arnaout, Walid S., additional, Imagawa, David K., additional, Colquhoun, Steven D., additional, Fraiman, Mark H., additional, McDiarmid, Sue V., additional, and Busuttil, Ronald W., additional

Published
1997
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21. RETRANSPLANTATION IN MINIATURE SWINE

Author

ROSENGARD, BRUCE R., primary, FISHBEIN, JONATHAN M., additional, GIANELLO, PIERRE, additional, OJIKUTU, CHRISTINA A., additional, GUZZETTA, PHILIP C., additional, SMITH, CRAIG V., additional, SUNDT, THORALF M., additional, NAKAJIMA, KAZUAKI, additional, HILL, GARY S., additional, and SACHS, DAVID H., additional

Published
1994
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22. BONE MARROW TRANSPLANTATION IN MINIATURE SWINE

Author

SMITH, CRAIG V., primary, SUZUKI, TAKAO, additional, GUZZETTA, PHILIP C., additional, NAKAJIMA, KAZUAKI, additional, SUNDT, THORALF M., additional, MIXON, ARNOLD, additional, SPITZER, THOMAS R., additional, ECKHAUS, MICHAEL A., additional, and SACHS, DAVID H., additional

Published
1993
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25. THE FAILURE OF SKIN GRAFTING TO BREAK TOLERANCE TO CLASS I-DISPARATE RENAL ALLOGRAFTS IN MINIATURE SWINE DESPITE INDUCING MARKED ANTIDONOR CELLULAR IMMUNITY

Author

ROSENGARD, BRUCE R., primary, KORTZ, ERIC O., additional, OJIKUTU, CHRISTINA A., additional, GUZZETTA, PHILIP C., additional, SUNDT, THORALF M., additional, SMITH, CRAIG V., additional, NAKAJIMA, KAZUAKI, additional, BOORSTEIN, STEPHEN M., additional, HILL, GARY S., additional, and SACHS, DAVID H., additional

Published
1991
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31. INDUCTION OF SPECIFIC TOLERANCE TO CLASS IDISPARATE RENAL ALLOGRAFTS IN MINIATURE SWINE WITH CYCLOSPORINE

Author

ROSENGARD, BRUCE R., OJIKUTU, CHRISTINA A., GUZZETTA, PHILIP C., SMITH, CRAIG V., SUNDT, THORALF M., NAKAJIMA, KAZUAKI, BOORSTEIN, STEPHEN M., HILL, GARY S., FISHBEIN, JONATHAN M., and SACHS, DAVID H.

Abstract

Previous studies in miniature swine have suggested that the mechanism underlying the spontaneous development of tolerance in one third of one-haplotype class I disparate renal allografts (i.e., ag→ad) involves a relative T cell help deficit at the time of first exposure to antigen. If this hypothesis were correct, then one might expect the administration of an immunosuppressive agent capable of inhibiting lymphokine production during this period to lead to the induction of tolerance to class I MHC antigens in two-haplotype class I mismatched renal allografts (i.e., gg→dd), which are otherwise uniformly and acutely rejected. This hypothesis was tested in eight two-haplotype class I disparate, class II matched donor-recipient pairs, in which recipients were treated with cyclosporine 10 mg/kg, i.v. q.d. for 12 days. This protocol led to the induction of long-term (>100 days) specific tolerance in 100 of recipients, as compared with control animals that rejected grafts in 13.7 ± 0.9 days (P<0.0001). The specificity of tolerance was assessed both in vivo

Published
1992

32. THE FAILURE OF SKIN GRAFTING TO BREAK TOLERANCE TO CLASS IDISPARATE RENAL ALLOGRAFTS IN MINIATURE SWINE DESPITE INDUCING MARKED ANTIDONOR CELLULAR IMMUNITY

Author

ROSENGARD, BRUCE R., KORTZ, ERIC O., OJIKUTU, CHRISTINA A., GUZZETTA, PHILIP C., SUNDT, THORALF M., SMITH, CRAIG V., NAKAJIMA, KAZUAKI, BOORSTEIN, STEPHEN M., HILL, GARY S., and SACHS, DAVID H.

Abstract

Long-term specific tolerance to one haplotype class I plus minor antigen disparate renal allografts develops without exogenous immunosuppression in approximately 35 of miniature swine (n=128). Previous studies have suggested that this phenomenon is related to limited class I-specific helper T cell activity as evidenced by the failure of antibody class switching in vivo and the ability of exogenous interleukin 2 to elicit antidonor responses in vitro. To determine whether tolerance could be broken by inducing antidonor reactivity with donor antigen and a source of T cell help, multiple skin grafts bearing donor class I plus third-party class II antigens were placed on tolerant animals. Skin grafts were placed at least 3 months after the kidney transplant, at which time all recipients had normal renal function as measured by blood urea nitrogen and serum creatinine. First-set rejection of skin grafts by SLAadand SLAddhosts occurred in 11.8±1.1 days (mean ± SEM, n=6) and in 9.3±0.9 days (n=4), respectively. Coincident with skin rejection, most animals developed a transient rise in BUN to 62±11 mg/dl (n=10) and a similar rise in Cr to 4.9±1.2 mg/dl (n=10), with normal levels returning in all animals within two weeks. Subsequent skin grafts with the same disparity did not undergo second-set rejection and did not induce BUN or Cr elevations. Prior to skin grafting, animals showed no antidonor activity in mixed lymphocyte reaction or cellmediated lymphocytotoxicity assays. After two skin grafts, all animals developed donor-specific CML and secondary MLR responses, and additional skin grafts amplified this cellular immunity. Development of marked antidonor immunity without a break in tolerance suggested that either graft adaptation or local suppression might be involved in maintaining tolerance to class I MHC antigens. In preliminary studies, an immunized SLAadanimal and an immunized SLAddanimal were retransplanted with kidneys MHC matched to their first allografts. In both cases, the second graft was accepted permanently without immunosuppression, suggesting that graft adaptation is not necessary for the maintenance of tolerance to renal allografts in miniature swine.

Published
1991

33. BETAADRENERGIC RECEPTOR SENSITIVITY AND GUANINE NUCLEOTIDE REGULATORY PROTEINS IN TRANSPLANTED HUMAN HEARTS AND AUTOTRANSPLANTED BABOONS

Author

HORN, EVELYN M., DANILO, PETER, APFELBAUM, MARK A., BARR, MARK L., PEPINO, PAOLO, POWERS, ERIC R., SMITH, CRAIG R., ROSE, ERIC A., and BILEZIKIAN, JOHN P.

Abstract

This study was conducted in human subjects and in baboons to assess elements of the β-adrenergic receptor complex in vivo and in vitro following cardiac transplantation. In human subjects, the concentration at which administered isoproterenol increased heart rate by 25 beats per min was within the normal range (mean, 3.2±0.4 μg). Myocardial biopsies and lymphocytes were obtained from 14 transplant recipients undergoing routine right heart catheterization. The stimulatory guanine nucleotide regulatory protein, Gs, was significantly greater in the lymphocyte than in right ventricular myocardium (5.8±1.7 vs. 2.0±0.5 relative to standard rat heart membrane preparation, P<0.05). In contrast, Gi was significantly greater in the myocardium than in the lymphocyte (4.2±1.3 vs. l.l±0.3, P<0.025). There was no correlation between lymphocyte and cardiac G protein determinations.

Published
1991

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