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Your search keyword '"Robyn G. Langham"' showing total 3 results
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3 results on '"Robyn G. Langham"'

1. Refractory Vascular Rejection in a Hand Allograft in the Presence of Antibodies Against Angiotensin II (Type 1) Receptor

Author

Wayne A. Morrison, Robyn G Langham, Prue Hill, Christopher M. Baker, Karen M. Dwyer, Samantha Bateman, and Robert P. Carroll

Subjects
0301 basic medicine, Transplantation, Angiotensin II receptor type 1, biology, business.industry, Pharmacology, Angiotensin II, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Refractory, Renin–angiotensin system, Immunology, biology.protein, Medicine, Antibody, business, Receptor, Hand transplantation, 030215 immunology
Published
2017
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2. TRANSFORMING GROWTH FACTOR-??1 AND TUMOR GROWTH FACTOR-??-INDUCIBLE GENE-H3 IN NONRENAL TRANSPLANT CYCLOSPORINE NEPHROPATHY

Author

Richard E. Gilbert, Melissa Egan, John P. Dowling, Napier M. Thomson, and Robyn G Langham

Subjects
Adult, medicine.medical_specialty, Heart-Lung Transplantation, medicine.medical_treatment, Biology, Kidney, Nephropathy, Transforming Growth Factor beta1, Gene product, Transforming Growth Factor beta, Internal medicine, Gene expression, medicine, Humans, RNA, Messenger, Kidney Tubules, Distal, Extracellular Matrix Proteins, Transplantation, Growth factor, Angiotensin-converting enzyme, Middle Aged, medicine.disease, Neoplasm Proteins, Cytokine, Endocrinology, Cyclosporine, biology.protein, Heart Transplantation, Kidney Diseases, Immunosuppressive Agents, Transforming growth factor
Abstract

Cyclosporine nephropathy (CyAN) is a major limiting factor in the otherwise successful widespread use of cyclosporine in solid organ transplant. Transforming growth factor-beta1 (TGF-beta1) has been implicated as an important fibrogenic cytokine in the development of this disease. TGF-beta-inducible gene-H3 (beta(ig)-H3) is a TGF-beta1- induced gene product, which acts as a marker for biologically active TGF-beta1. This study reports TGF-beta1 gene expression and beta(ig)-H3 tissue distribution in non-renal allograft CyAN. Renal tissue from nine patients who had developed CyAN after successful heart or heart-lung transplantation and from four kidneys removed for tumour were analyzed for TGF-beta1 gene expression beta(ig)-H3 protein with reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry, respectively. TGF-beta1 gene expression was increased in CyAN compared to nephrectomy (P

Published
2001
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